HPLC-ICP-MS Speciation Analysis of Arsenic in Urine of Japanese Subjects without Occupational Exposure
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概要
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HPLC-ICP-MS Speciation Analysis of Arsenic in Urine of Japanese Subjects without Occupational Exposure: Akihisa Hata. et al. Department of Preventive Medicine and Environmental Health, Graduate School of Medicine, Osaka City University-The toxicity and carcinogenicity of arsenic depend on its species. Individuals living in Japan consume much seafood that contains high levels of organoarsenics. Speciation analysis of urinary arsenic is required to clarify the health risks of arsenic intake. There has been no report of urinary arsenic analysis in Japan using high performance liquid chromatography with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). We performed speciation analysis of urinary arsenic for 210 Japanese male subjects without occupational exposure using HPLC-ICP-MS. The median values of urinary arsenics were as follows: sodium arsenite (AsIII), 3.5; sodium arsenate (AsV), 0.1; monomethylarsonic acid (MMA), 3.1 ; dimethylarsinic acid (DMA), 42.6; arsenobetaine (AsBe), 61.3; arsenocholine, trimethylarsine oxide, and unidentified arsenics (others), 5.2; and total arsenic (totalAs), 141.3 μgAs//. The median creatinine-adjusted values were as follows: AsIII, 3.0; AsV, 0.1 ; MMA, 2.6; DMA, 35.9; AsBe, 52.1 ; others 3.5; and total As, 114.9 μgAs/g creatinine. Our findings indicate that DMA and AsBe levels in Japan are much higher than those found in Italian and American studies. It appears that the high levels of DMA and AsBe observed in Japan may be due in part to seafood intake. ACGIH and DFG set the BEI and BAT values for occupational arsenic exposure as 35μgAs//and 50μgAs//, respectively, using the sum of inorganic arsenic (iAs), MMA, and DMA. In the general Japanese population, the sums of these were above 50μgAs// in 115 (55%) samples. We therefore recommend excluding DMA concentration in monitoring of iAs exposure.
著者
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Endo Yoko
Research Center for Occupational Poisoning, Tokyo Rosai Hospital
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Endo Ginji
Department of Preventive Medicine and Environmental Health, Osaka City University Medical School
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Endo Yoko
Res. Center For Occupational Poisoning Tokyo Rosai Hospital Japan Labour Health And Welfare Organiza
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Endo Yoko
Clinical Research Center For Occupational Poisoning Tokyo Rosai Hospital Japan Labour Health And Wel
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Endo Ginji
Department Of Preventive Medicine And Environmental Health Graduate School Of Medicine Osaka City Un
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Endo Ginji
Department Of Preventive Medicine And Environmental Health Osaka City University Medical School
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Endo Ginji
Department Of Environmental Health Medical School Osaka City University
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NAKAJIMA Yoshiaki
Research Center for Occupational Poisoning, Tokyo Rosai Hospital
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OGAWA Masanori
Research Center for Occupational Poisoning, Tokyo Rosai Hospital, Japan Labour Health and Welfare Or
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HATA Akihisa
Department of Preventive Medicine and Environmental Health, Graduate School of Medicine, Osaka City
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Hata Akihisa
Department Of Preventive Medicine And Environmental Health Graduate School Of Medicine Osaka City Un
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Fujitani Noboru
Division Of Clinical Laboratory Science Department Of Environmental Security System Faculty Of Risk
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IKEBE Maiko
Department of Preventive Medicine and Environmental Health, Graduate School of Medicine, Osaka City
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Ikebe Maiko
Department Of Preventive Medicine And Environmental Health Graduate School Of Medicine Osaka City Un
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Endo Yoko
Research Center For Occupational Poisoning Kansai Rosai Hospital Japan Labour Health And Welfare Org
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Nakajima Yoshiaki
Research Center For Occupational Poisoning Tokyo Rosai Hospital Japan Labour Health And Welfare Orga
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Nakajima Yoshiaki
Research Center For Occupational Poisoning Tokyo Rosai Hospital
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Endo Yoko
Research Center For Occupational Poisoning Tokyo Rosai Hospital Japan Labour Health Organization
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