Effects of Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) on Hyperglycemia in Streptozotocin-Induced Diabetic Rats(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
The present study investigated the effects of Hachimi-jio-gan (HJ) on diabetic hyperglycemia in streptozotocin (STZ)-induced diabetic rats. After STZ administration, rats had free access to pellets containing 1% HJ extract powder for four weeks. HJ markedly suppressed hyperglycemia in STZ-induced diabetic rats at three and four weeks after the start of administration. There were also significant increases in serum and pancreatic immunoreactive insulin levels in STZ and HJ co-administering rats. However, in the present study, the number of β cells in the pancreatic Langerhans' islets did not increase. Next, in order to investigate the action mechanism besides the glycemic control action of insulin, the expression of glucose transporter 2 (GLUT2) protein, which is involved in glucose uptake and release in the liver, was investigated. GLUT2 protein expression was increased by STZ administration but was normalized after four weeks of HJ administration. Therefore, irrespective of the structural changes in pancreatic β-cells due to STZ, HJ increased insulin production and secretion by the pancreas and significantly suppressed GLUT2 synthesis in the liver. Amylase secretion from the pancreas was measured to assess pancreatic secretion. Amylase activity was decreased by STZ but was increased by HJ. Therefore, the effects of HJ on STZ-induced hyperglycemia in rats could be summarized as follows: besides increasing insulin synthesis and release, HJ normalizes GLUT2 protein expression in the liver to suppress hyperglycemia. Hence, the results of the present study suggest for the first time that HJ affects not only the production and secretion of insulin, but also the release of glucose from the liver.
- 社団法人日本薬学会の論文
- 2007-05-01
著者
-
HIROTANI Yoshihiko
Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohtani University
-
Hirotani Yoshihiko
Laboratory Of Clinical Pharmaceutics Faculty Of Pharmacy Osaka Ohtani University
-
Hirotani Yoshihiko
大阪薬科大学 臨床薬剤学研究室
-
IKEDA Takuya
Department of Pharmacy, Osaka University Hospital
-
YAMAMOTO Kaoru
Department of Pharmacy, Osaka University Hospital
-
KUROKAWA Nobuo
Department of Pharmacy, Osaka University Hospital
-
Hirotani Yoshihiko
Faculty Of Pharmaceutical Sciences Osaka Ohtani University
-
Ikeda Takuya
Department Of Neurosurgery Osaka University Medical School
-
Yamamoto Kaoru
Department Of Pharmacy Osaka University Hospital
-
Kurokawa Nobuo
Department Of Pharmacy Osaka University Hospital
-
Hirotani Yoshihiko
大阪大谷大学 薬学部臨床薬剤学
-
Yamamoto Kaoru
Department Of Endocrinology And Metabolism National Research Institute For Child Health And Developm
-
Ikeda Takuya
Department Of Pharmacy Osaka University Hospital
-
Yamamoto Kaoru
Department Of Chemistry Graduate School Of Science Tohoku University
-
Kurokawa Nobuo
Dep. Of Pharmacy Osaka Univ. Hospital
-
Ikeda Takuya
Department Of Neruosurgery Osaka University
関連論文
- Prediction of Cibenzoline Dose from that of Digoxin
- Effects of CpG-DNA from Escherichia coli on Digoxin Pharmacokinetics(Biopharmacy)
- Changes in Digoxin Pharmacokinetics Treated with Lipopolysaccharide in Wistar Rats(Biopharmacy)
- Effects of Capsaicin on Cellular Damage and Monolayer Permeability in Human Intestinal Caco-2 Cells(Biopharmacy)
- Effects of Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) on Hyperglycemia in Streptozotocin-Induced Diabetic Rats(Biopharmacy)
- Correlation between Plasma Glucagon-Like Peptide 2 Levels and Proliferative Makers in Small Intestinal Injury in Rats Induced by Methotrexate Administration(Biopharmacy)
- Protective Effects of Capsaicin against Cisplatin-Induced Nephrotoxicity in Rats(Pharmacology)
- Synthesis of Rat Glucagon-Like Peptide (GLP)-2 and Its Biological and Immunochemical Studies
- B-75. Estimation of tumor Sizr on Brain Scintigram
- B-6. Digital Analysis of Scintigram of Brain Tumor
- The Impact of New-onset Diabetes on Arterial Stiffness after Renal Transplantation
- A-47. Argon Laser Treatment of Brain Tumors
- B-21. Basic Experiment to Apply Laser Radiation for Treatment of Brain Tumors
- s-3. Effect of hyperbaric oxygenation on cerebral damage
- e-25. Effects of Laser Radiation Upon the Transplanted Brain Tumor with Exogenous Photosensitizer
- c-4. A Case of Malignant THYmoma with Spinal COmpression Sympom and Metastasis to the Skull
- S-B-8. Effect of Hyperbaric Oxygenation on Cerebral Edema
- PDX-1 and MafA Play a Crucial Role in Pancreatic β-Cell Differentiation and Maintenance of Mature β-Cell Function
- 13. Electromyographical study for indication of stereoencephalotomy
- Examination of Purification Methods and Development of Intravitreal Injection of Triamcinolone Acetonide
- 45. Subcortical or Brainstem Lesion Effect on Subcorticogenic Seizure with special Reference to the Forel-H Field : experimental analysis (Proceedings of the XXVth Annual Meeting of the Japan Neurosurgical Society)
- Pulmonary Cryptococcosis with a Solitary Focal Ground-glass Opacity on High-resolution Computed Tomography
- Role of Copper Ion in the Pathogenesis of Type 2 Diabetes
- Terahertz Absorption Spectra of Original and Generic Ceftazidime
- Effects of Hachimijiogan (Ba-Wei-Di-Huang-Wan) on renal aldose reductase activity in streptozotocin-induced diabetic rats
- Effect of Duration of Hyperglycemia on Osseointegration around Titanium Implants
- 35. Clinical Results of Forel-H-tomy of the Treatment of Epilepsy
- 17. Indications of forel-H-tomy for the treatment of epilepsy
- Differential stereoselective effects of levobupivacaine, bupivacaine and dexbupivacaine on the heart in isolated rat hearts
- 10 Brain Stem or Lenticular Nucleus Lesion Effect on Epileptogenic Convulsion elicited by Intravenous Administration of Metrazol (Preliminary Report)
- Pharmacokinetic Behavior of Intravitreal Triamcinolone Acetonide Prepared by a Hospital Pharmacy
- Intraocular Concentration of Intravenous Prednisolone in Experimental Autoimmune Uveoretinitis Mice
- Influence of Heat Treatment on the Distribution of Ni_2Nb and Microsegregation in Cast Inconel 718 Alloy
- Influence of Rhenium and Cooling Rate on the Solidification of Ni Base Superalloys, Inconel 718
- Pharmacokinetic Evaluation of Anticonvulsants in a Patient with Porphyria
- Solidification Process and Behavior of Alloying Elements in Ni-Based Superalloy Inconel718
- 21. Forel-H-Tomy for the Treatment of Lennox Syndrome
- KRAS Analysis in 34 Noonan Syndrome Patients without PTPN11 Mutation
- SNP Studies on the Structure of the Short-Lived Radical Pair Generated in the Hydrogen Abstraction Reaction of Anthraquinone from Xanthene
- Application of Terahertz Absorption Spectroscopy to Evaluation of Aging Variation of Medicine
- A New Alarm Device for Air Embolism during Neurosurgery in the Sitting Position
- Influence of Nb and V on the Microstructure of Ni-Hard Type Cast Iron for Hot Steel Strip Mill
- Solidification Microstructures and Quench/Temper Hardness of Tantalum Added High-Carbon High-Speed Steel Type Cast Alloy
- Novel Bistable Device Using Anchoring Transition and Command Surface
- Correlation between the Consumption of Meropenem or Doripenem and Meropenem Susceptibility of Pseudomonas aeruginosa in a University Hospital in Japan
- Novel Bistable Device Using Anchoring Transition and Command Surface