Protective Effects of Capsaicin against Cisplatin-Induced Nephrotoxicity in Rats(Pharmacology)

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概要

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• Cisplatin-induced nephrotoxicity is related to an increase in lipid peroxidation and oxygen free radicals in a kidney. In the present study, we investigated the effect of the dietary antioxidants, capsaicin (Cap), against cis-platin-induced lipid peroxidation and nephrotoxicity in rats. Nephrotoxicity induced by treatment with a single dose of cisplatin (5mg/kg body weight i.p.). The animals were divided into 4 groups. Cap (10mg/kg/d) was given by gavage from the same day of cisplatin injection. Cisplatin administration resulted in significant increases in the kidney weight as a percentage of the total body weight, urine volume, serum creatinine, and blood urea nitrogen by about 132, 315, 797, and 556% in comparison with the control rats, respectively (p<0.05). Also, the renal tissue from the cisplatin-treated rats showed significant decreases in the kidney glutathione (GSH) content and superoxide dismustase (SOD) activity and a significant increase in malondialdehyde (MDA) production in comparison to the values at 0h (p<0.05). Seven days after Cap plus cisplatin treatments, the renal damage induced by cisplatin recovered to a significant statistically level. In addition, Cap prevented the rise of MDA and the reduction of SOD activities. These results suggest that Cap has protective effects against cisplatin-induced nephrotoxicity and lipid peroxidation in rats.

• 社団法人日本薬学会の論文
• 2005-09-01

著者

• TANAKA Kazuhiko

  Department of Clinical Pharmacology & Pharmacokinetics, Osaka University of Pharmaceutical Sciences

• SHIMEDA Yuka

  Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sc

• NISHIHORI Takako

  Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sc

• HIROTANI Yoshihiko

  Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sc

• Shimeda Yuka

  大阪薬科大学 臨床薬剤学

• Shimeda Yuka

  Department Of Clinical Pharmacy & Clinical Pharmacokinetics Osaka University Of Pharmaceutical S

• Shimeda Yuka

  Department Of Clinical Pharmacy And Clinical Pharmacokinetics Osaka University Of Pharmaceutical Sci

• HIROTANI Yoshihiko

  Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohtani University

• Ijiri Yoshio

  大阪薬科大学 臨床薬剤学研究室

• Ijiri Yoshio

  Laboratory Of Clinical Pharmacy And Clinical Pharmacokinetics Osaka University Of Pharmaceutical Sci

• Ijiri Yoshio

  Department Of Pharmacy Osaka Medical College Hospital

• Hirotani Yoshihiko

  Laboratory Of Clinical Pharmaceutics Faculty Of Pharmacy Osaka Ohtani University

• Hirotani Yoshihiko

  大阪薬科大学 臨床薬剤学研究室

• AKIMOTO Youko

  Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Scie

• SHINDOU Kyoko

  Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Scie

• Ijiri Yoshio

  Department Of Clinical Pharmacy And Clinical Pharmacokinetics Osaka University Of Pharmaceutical Sci

• Tanaka Kazuhiko

  Department Of Cardiology Dokkyo Medical University Koshigaya Hospital

• Tanaka Kazuhiko

  Department Of Clinical Pharmacology & Pharmacokinetics Osaka University Of Pharmaceutical Scienc

• Akimoto Youko

  Department Of Clinical Pharmacy & Clinical Pharmacokinetics Osaka University Of Pharmaceutical S

• Shindou Kyoko

  Department Of Clinical Pharmacy & Clinical Pharmacokinetics Osaka University Of Pharmaceutical S

• Nishihori Takako

  Department Of Clinical Pharmacy & Clinical Pharmacokinetics Osaka University Of Pharmaceutical S

• Hirotani Yoshihiko

  大阪大谷大学 薬学部臨床薬剤学

• Tanaka Kazuhiko

  Department Mechanical Engineering Fukui Technology College

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