Cigarette-Smoke-Induced Vasoconstriction of Peripheral Arteries : Evaluation by Synchrotron Radiation Microangiography

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Background Although cigarette smoking is thought to constrict peripheral vessels, details have not been clarified because of the limitation of spatial resolution in conventional X-ray angiography systems. Synchrotron radiation microangiography can identify small arteries down to 50/mi in diameter. Method and Results Male Wistar rats(n=9) were made to smoke a cigarette using the modified Griffith snout exposure system. Angiography of the rat hind limb was performed before, during, and 15min after smoking. Arteries were classified into 3 groups based on the pre-smoking diameter: Group S: <100μm, Group M 100-20μm, Group L: >2μm). In Groups M and L, arteries were constricted with smoking(mean diameter 140-106μm; p<0.001, 260-162μm; p<0.00001, respectively), whereas no constriction was noted in Group S(82-83μm). Constricted arteries in Groups M and L returned to pre-smoking levels at 15min after cessation of smoking. Conclusion The acute changes brought about by cigarette smoking in rat peripheral arteries could be identifiedby synchrotron radiation microangiography. Cigarette smoking exclusively constricted arteries greater than 100μm in diameter, which means there is vessel-size dependency of the impairment.
社団法人日本循環器学会の論文
2007-02-20