イヌの実験的歯肉炎におけるコラゲナーゼ活性について : 第2報 炎症発生期間を短縮したときの動態
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The previous study showed that the collagenase activities in salt extract and two sonicates were significantly higher in inflamed gingiva after 3 weeks of plaque forming period than healthy gingiva in dogs, respectively. The aim of this study was to extract the collagenase and gelatinase from the healthy and inflamed gingivae after 1 week of plaque forming period and compare their activities with those of 3 week-old gingivitis. With inflamed gingiva after 1 week of plaque forming period, two forms of collagenase, the soluble enzyme free its substrate and insoluble enzyme bound to the substrate, were extracted according to the methods as described previously. Collagenase activity was measured using [^<14>C]-acetylated collagen with high specific activity in solution as substrate and separating the reaction products by 50% dioxane. Treatment with a high concentration of trypsin was also necessary for detection of collagenase activities in all the extracts as in the case of experimentally induced 3 week-old gingivitis. The collagenase activities in salt extract and the first sonicate were significantly higher in inflamed gingiva after 1 week of plaque forming period than in healthy gingiva respectively, but that of the second sonicate showed no significant increase. Furthermore, the rates of the increase in two fractions were smaller than those in 3 week-old gingivitis. From these results, it is suggested that both soluble and insoluble forms of collagenase in dog start to increase within 1 week after the induction of inflammation and continue the increase for at least 2 weeks. On the other hand, gelatinase activity did not vary significantly by the induction of inflammation.
- 特定非営利活動法人日本歯周病学会の論文
- 1981-12-28
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