Beta-Adrenergic Agonist Therapy for Alveolar Edema in Postoperative Pulmonary Complications

概要

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Over the past one and a half decade, we have established and developed an ex vivo human lung model for the investigation of alveolar fluid reabsorption (alveolar fluid clearance) in the human lung. Alveolar fluid clearance primarily depends on active sodium transport via apical sodium channel and basolateral Na^+-K^+ ATPase on alveolar epithelial cells. Beta-adrenergic agonists stimulate β_1^- and β_2^-, but not β_3^-adrenergic receptors followed by the increase of CAMP and alveolar fluid clearance. Cystic fibrosis transmembrane conductance regulator plays a role in β-adrenergic agonist stimulated alveolar fluid clearance. Hypothermia followed by rewarming preserves alveolar fluid clearance capacity and the function of β-receptors, the results are favorable in the preservation of donor lung for lung transplantation. Since there was a species difference between alveolar fluid clearance among animals, our date from human lungs have contributed to the research area of ion and fluid transport on the alveolar epithelial cells and to the clinical area of pulmonary edema and lung injury.
金沢医科大学の論文