Novel Elongated Phosphoranes by Heck-Reaction and Pd(0)-Catalysed Alkynylation and their Use in C-7 Group Functionalisation in Estrones
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概要
- 論文の詳細を見る
Halobenzoylmethylidenephosphoranes 3 are reacted under C-C bond formation to give a number of novel elongated phosphoranes 5 and 6. The C-C bond formation could be achieved both under Heck conditions and by metal-catalyzed ethynylation reaction. The products, desactivated phosphoranes, can be reacted in Wittig-olefinations with aldehydes. Exemplary use of the phosphoranes is shown in the C-7 chain functionalisation in synthetic estrones, which may be valuable precursors for radioligands in early breast cancer diagnosis.
- 九州大学の論文
- 2000-07-01
著者
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Mataka S
Kyushu Univ. Kasuga
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Mataka Shuntaro
Department Of Molecular Science And Technology Graduate School Of Engineering Sciences Kyushu Univer
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Mataka Shuntaro
Institute Of Advanced Material Kyushu University
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Mataka Shuntaro
Institute Of Advanced Material Study Kyushu University
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THIEMANN Thies
Institute of Advanced Material Study, Kyushu University
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Thiemann T
Institute Of Advanced Material Study Kyushu University
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UMENO Kuniharu
Graduate School of Engineering Sciences, Kyushu University
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INOHAE Eiko
Graduate School of Engineering Sciences, Kyushu University
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Inohae Eiko
Graduate School Of Engineering Sciences Kyushu University
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Umeno Kuniharu
Graduate School Of Engineering Sciences Kyushu University
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