ヤーコン地上部の抗酸化活性とα-グルコシダーゼ阻害活性に関する成分

概要

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Hot water extract of the aerial part of Yacon (Smallanthus sonchifolia, Compositae) showed potent free radicalscavenging activity and inhibitory effects on lipid peroxidation in rat brain homogenate. The most potent antioxidative activity focused on the 50% MeOH-eluted fraction on DIAION HP-20 column chromatography. The structure of the major component in the fraction was identified as 2,3,5-tricaffeoylaltraric acid (TCAA) based on spectroscopic evidence. The antioxidative activity of TCAA is superior to that of natural antioxidants such as (±)-catechin, α-tocopherol, and ellagic acid, and TCAA also showed selective maltase-inhibitory activity (IC_<50> 49μg/ml). As the hypoglycemic activity of Yacon extract was described in a previous report, the present results showing that the aerial part of Yacon has strong antioxidative activity may encourage its potential use as a food supplement to prevent type II diabetes.
公益社団法人日本薬学会の論文
2006-08-01