Glycoprotein (90kDa) Isolated from Opuntia ficus-indica var. saboten MAKINO Lowers Plasma Lipid Level through Scavenging of Intracellular Radicals in Triton WR-1339-Induced Mice(Pharmacology)

スポンサーリンク

概要

• 論文の詳細を見る

• The Opuntia ficus-lndica var. saboten MAKINO (OFI) has been traditionally used as health food and herbal agent in folk medicine in Korea. In this study, we investigated whether the OFI glycoprotein has antioxidative activity and hypolipidemic effect on Triton WR-1339-induced A/J mice. The OFI glycoprotein inhibits the production of reactive oxygen species (ROS) generated by glucose/glucose oxidase (G/GO) in BNL CL.2 cells. With its antioxidative property, the mice were orally administered in the OFI glycoprotein [50mg/kg body weight (BW)] for two weeks. Our finding resulted in a significant decrease of plasma lipid levels in Triton WR-1339-treated mice such as total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL). Indeed, mice which induced by Triton WR-1339 were significantly increased the levels of TC, TG and LDL, whereas the high-density lipoprotein (HDL) level obviously decreased. However, the values were reversed at pretreatment with OFI glycoprotein in Triton WR-1339-treated mice. The data also showed that pretreatment with OFI glycoprotein resulted in decrease of thiobarbituric acid-reactive substances (TEARS) level and in increase of nitric oxide (NO) amount in presence of Triton WR-1339-treated mice, while the activities of antioxidant enzyme [superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] were augmented. Therefore, we speculate that the OFI glycoprotein would be effective in lowering of plasma lipid levels.

• 2006-07-01

著者

• Lim Kye-taek

  Molecular Biochemistry Lab. Biotechnology Res. Inst. Chonnam National Univ.

• Lim Kye-taek

  Molecular Biochemistry Laboratory Biotechnology Research Institute & Center For The Control Of A

• OH Phil-Sun

  #521, Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University

• LIM Kye-Taek

  #521, Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University

• Oh Phil-sun

  Molecular Biochemistry Lab. Biotechnology Res. Inst. & Center For The Control Of Animal Hazards

• Oh Phil-sun

  Molecular Biochemistry Laboratory Biotechnology Research Institute & Center For The Control Of A

• Lim Kye-taek

  Molecular Biochemistry Laboratory Biotechnology Research Institute Chonnam National University

関連論文

• Glycoprotein (90kDa) Isolated from Opuntia ficus-indica var. saboten MAKINO Lowers Plasma Lipid Level through Scavenging of Intracellular Radicals in Triton WR-1339-Induced Mice(Pharmacology)
• Glycoprotein Isolated From Ulmus davidiana NAKAI Protects Against Carbon Tetrachloride-Induced Liver Injury in the Mouse
• Glycoprotein Isolated from Rhus verniciflua STOKES Inhibits Inflammation-Related Protein and Nitric Oxide Production in LPS-Stimulated RAW 264.7 Cells(Pharmacology)
• Hypolipidemic and Antioxidative Effects of the Plant Glycoprotein (36kDa) from Rhus verniciflua Stokes Fruit in Triton WR-1339-Induced Hyperlipidemic Mice
• Inhibitory Effect of Phytoglycoprotein (115kDa) on the Expression of TNF-α and Interleukin-1β via Inhibition of MAP Kinase in Primary Cultured Mouse Thymocytes
• Plant Glycoprotein Modulates the Expression of Interleukin-1β via Inhibition of MAP Kinase in HMC-1 Cells

スポンサーリンク