Plant Glycoprotein Modulates the Expression of Interleukin-1β via Inhibition of MAP Kinase in HMC-1 Cells
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概要
- 論文の詳細を見る
Dioscorea batatas Decne (DBD) is used to heal various disorders of the kidney and lungs as an herbal agent in Korea. The purpose of the present study was to determine whether the DBD glycoprotein regulates the inflammatory reaction stimulated by phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI) in human mast cells (HMC-1). The results indicate that DBD glycoprotein decreased gene expression of interleukin (IL)-1β and cyclooxygenase (COX)-2 in PMACI-stimulated HMC-1 cells through blocking of phosphorylation of p44/42 mitogen-activated protein kinase (MAPK) and p38 MAPK and DNA binding activities of nuclear factor (NF)-κB and activator protein (AP)-1. The production of intracellular reactive oxygen species (ROS) and nitric oxide (NO) is gradually reduced by concentration-dependent DBD glycoprotein treatment in PMACI-stimulated HMC-1 cells. Hence, we propose the hypothesis that DBD glycoprotein can serve as a potent anti-inflammatory agent in the treatment of inflammatory allergic diseases through inhibition of inflammation-related signal transduction in mast cell activation.
- 社団法人 日本農芸化学会の論文
- 2008-08-23
著者
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Lim Kye-taek
Molecular Biochemistry Lab. Biotechnology Res. Inst. Chonnam National Univ.
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Oh Phil-sun
Molecular Biochemistry Lab. Biotechnology Res. Inst. & Center For The Control Of Animal Hazards
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Oh Phil-sun
Molecular Biochemistry Laboratory Biotechnology Research Institute & Center For The Control Of A
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Lim Kye-taek
Molecular Biochemistry Laboratory Biotechnology Research Institute Chonnam National University
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