Glycoprotein Isolated From Ulmus davidiana NAKAI Protects Against Carbon Tetrachloride-Induced Liver Injury in the Mouse

スポンサーリンク

概要

• 論文の詳細を見る

• Ulmus davidiana N<sc>AKAI</sc> (UDN) has traditionally been used for healing of inflammatory diseases. This study was carried out to investigate the hepatoprotective effect of the glycoprotein isolated from UDN in carbon tetrachloride (CCl4)-induced liver injury. We evaluated the activities of alanine aminotransferase (ALT), lactate dehydrogenase (LDH), thiobarbituric acid-reactive substances (TBARS), and antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)] activities in CCl4-treated mice. When mice were treated with CCl4 in the absence of UDN glycoprotein, the activities of ALT, LDH, and TBARS were increased, while the antioxidant enzymes activities were decreased. However, when the mice were treated with CCl4 in the presence of UDN glycoprotein, the activities of ALT, LDH, and TBARS were significantly reduced and SOD, CAT, and GPx activities were remarkably increased. In addition, UDN glycoprotein increased the nitric oxide production and decreased the nuclear factor-kappa B and activator protein-1 activation in CCl4-treated mice. We also investigated the protective effects of UDN glycoprotein in glucose/glucose oxidase (G/GO)-induced cytotoxicity in primary cultured mouse hepatocytes. UDN glycoprotein markedly inhibited the cell death induced by G/GO. These results suggest that UDN glycoprotein protects against CCl4-induced liver injury in the mouse.

• 2006-07-20

著者

• Ko Jeong-hyeon

  #521 Molecular Biochemistry Laboratory Institute Of Biotechnology Chonnam National University

• LIM Kye-Taek

  #521, Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University

• Lim Kye-taek

  #521 Molecular Biochemistry Laboratory Institute Of Biotechnology Chonnam National University

• KO Jeong-Hyeon

  #521, Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University

関連論文

• Glycoprotein (90kDa) Isolated from Opuntia ficus-indica var. saboten MAKINO Lowers Plasma Lipid Level through Scavenging of Intracellular Radicals in Triton WR-1339-Induced Mice(Pharmacology)
• Glycoprotein Isolated From Ulmus davidiana NAKAI Protects Against Carbon Tetrachloride-Induced Liver Injury in the Mouse

スポンサーリンク