A Patient with Influenza A-associated Encephalopathy Treated with Mild Hypothermic Therapy and Methylprednisolone Pulse Therapy

概要

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A case of influenza A-associated acute encephalopathy treated with mild hypothermic therapy and methylprednisolone pulse therapy is reported. The patient was a 1 year and 1 month-old girl. Disturbance of consciousness was protracted after fever accompanied by status convulsives, thus she was diagnosed with acute encephalopathy. Influenza A reaction was positive on rapid diagnosis from her nasal mucosa. Hypothermic therapy was initiated in the early stage, and body temperature was kept at 35℃ as rectal and ear drum membrane temperatures for 72 hours. As steroid therapy, 30mg/kg/day methylprednisolone was administered for 3 days. During the course, 7mg/kg amantadine was administered for 5 days. After the combination of therapy, the patient recovered without sequela. No major adverse event occurred during the combined therapy. Still now, there are no established clinical guidelines for this encephalopathy. The combined therapy was effective for influenza A-associated encephalopathy in this patient.
獨協医科大学の論文
2005-10-25