Human Prostate Cancer Xenograft as a Tool for Screening of Efficacious Antiandrogens

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概要

• 論文の詳細を見る

• The efficacies of the steroidal antiandrogens chlormadinone acetate (CMA), 17 α-acetoxy-6-chloro-2-oxa-4, 6-pregnadiene-3, 20-dione (TZP), and cyproterone acetate (CypA) for retardation of the growth of androgen-dependent human prostatic adenocarcinoma transplanted into nude mice (Honda tumor) were tested. CypA inhibited the growth of these tumors, while CMA and TZP did not affect the weight of cancer tissue at the doses examined. Serum levels of human prostatic acid phosphatase (PAP) in the tumor-bearing mice were very sensitive to the administration of antiandrogens, but the levels were not dependent on the changes in tumor weight. In contrast, human prostate-specific antigen (PSA) levels in the blood of the host mice were correlated with the weight of the tumors, and were independent of treatment with antiandrogens. Castration of the cancer-bearing mice resulted in reductions in all experimental parameters tested. The validity of PSA-secreting androgen-dependent human prostate cancer xenograft as a tool for screening of efficacious antiandrogens will be discussed.

• 群馬大学の論文
• 1997-03-31

著者

• HIROMACHI Sachiko

  Department of Nursing Science, Gunma University College of Health Sciences

• Arai Michiko

  Department Of Nursing College Of Health Sciences Gunma University

• Ito Yoshikazu

  Department Of Nursing College Of Health Sciences Gunma University

• Ito Yoshikazu

  Department Of Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Technology

• FUTAWATARI Tamae

  Gunma Prefectural College of Health Sciences

• Hiromachi Sachiko

  Department Of Nursing College Of Health Sciences Gunma University

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• ESTABLISHMENT AND PARTIAL CHARACTERIZATION OF A NEW TUMORIGENIC EPITHELIAL-LIKE CELL LINE FROM RAT VENTRAL PROSTATE
• Antineoplastic Effects of Interferon-Alpha and -Gamma in Metastatic Renal Cell Carcinoma Xenografts in Nude Mice
• Pd Nanoparticle Embedded with Only One Co Atom Behaves as a Single-Particle Magnet(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• PRESERVATION OF ADULT HUMAN SPERMATOGENIC CELLS BY TESTICULAR TISSUE XENOGRAFTING TO CASTRATED IMMUNODEFICIENT MICE(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
• Effect of Fatty Acids and Prostaglandin on Androgen Receptor Binding in Human Prostatic Cancer Cells
• Human Prostate Cancer Xenograft as a Tool for Screening of Efficacious Antiandrogens
• LIMITED EFFECTS OF ANTIANDROGENS AND GONADOTROPIN-RELEASING HORMONE AGONIST ON TRANSPLANTABLE HUMAN PROSTATIC CANCER HONDA
• In Vitro Effect of Testosterone and its Metabolites on the Synthesis of Protein in the Prostate Glands of Immature Rats
• Effect of Hypolipidemia on Testosterone-Stimulated Prostatic Growth in Castrated Rats

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