Antineoplastic Effects of Interferon-Alpha and -Gamma in Metastatic Renal Cell Carcinoma Xenografts in Nude Mice
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概要
- 論文の詳細を見る
Combination treatment with human natural interferon-alpha (IFN-alpha) and natural interferon-gamma (IFN-gamma) markedly reduced the weight of metastatic human renal cell carcinoma (RCC) transplanted into nude mice. Monotherapy with IFN-alpha or IFN-gamma inhibited the tumor growth without reducing the tumor weight. After combination treatment with IFN-alpha and-gamma, histological features showed notable reduction in the number of mitotic tumor cells and appreciable fibrosis in the stroma of the tumor. Infiltration of macrophages in the tumor was sparse. The results suggested that the antitumor activity of the IFNs is by direct cellular action. The general condition of tumor-bearing mice treated with IFN-alpha and-gamma was well retained, while marked emaciation was observed in the untreated tumor-bearing animals. The finding indicated that the combination treatment of RCC with IFN-alpha and-gamma may reduce the tumor burden of host mice.
- 群馬大学の論文
- 1994-03-31
著者
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NAKAZATO Yoichi
Department of Pathology, Gunma University Graduate School of Medicine
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Nakazato Yoichi
Department Of Human Pathology Gunma University Graduate School Of Medicine
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Nakazato Yoichi
Department Of Pathology Gunma University School Of Medicine
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ITO Yoshikazu
Department of Nursing Science, Gunma University College of Health Sciences
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HIROMACHI Sachiko
Department of Nursing Science, Gunma University College of Health Sciences
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FUTAWATARI Tamae
Department of Nursing, Gunma Prefectural College of Health Sciences
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ARAI Michiko
Department of Nursing Science, Gunma University College of Health Sciences
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SHIRAHAMA Akiko
Department of Nursing Science, Gunma University College of Health Sciences
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Arai Michiko
Department Of Nursing College Of Health Sciences Gunma University
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Ito Yoshikazu
Department Of Nursing College Of Health Sciences Gunma University
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Ito Yoshikazu
Department Of Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Technology
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Shirahama Akiko
Department Of Nursing Science Gunma University College Of Health Sciences
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FUTAWATARI Tamae
Gunma Prefectural College of Health Sciences
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Hiromachi Sachiko
Department Of Nursing College Of Health Sciences Gunma University
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NAKAZATO Yoichi
Department of Pathology, Gunma University School of Medicine
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