ESTABLISHMENT AND PARTIAL CHARACTERIZATION OF A NEW TUMORIGENIC EPITHELIAL-LIKE CELL LINE FROM RAT VENTRAL PROSTATE
スポンサーリンク
概要
- 論文の詳細を見る
A tumorigenic epithelial-like cell line of rat prostate origin (PR4) was established in vitro. The cell line originated from a single cell of a previously established rat ventral prostate cell line, and has been serially subcultured more than 100 times over 5 years. The doubling time of the cells was 18 hours, and the saturation density was 5 x 10(6) cells/ml. Oval nuclei with dispersed chromatin and well developed cytoplasmic organelles were ultrastructural characteristics of the cells. The PR4 cells were transplanted into nude mice and the histology of the resulting tumors was neopolastic epithelial-like morphology that showed cells arranged in a sheet and cord structure with a solid pattern. Very high activities of prostatic acid phosphatase and beta-glucuronidase were observed in the cytosol of the cells. The PR4 cells did not respond to androgen. The use of the new cell line and other in vitro models of rat prostate as experimental tools for human prostatic cancer research was discussed.
- 群馬大学の論文
- 1996-03-31
著者
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NAKAZATO Yoichi
Department of Pathology, Gunma University Graduate School of Medicine
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Nakazato Yoichi
Department Of Human Pathology Gunma University Graduate School Of Medicine
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Nakazato Yoichi
Department Of Pathology Gunma University School Of Medicine
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ITO Yoshikazu
Department of Nursing Science, Gunma University College of Health Sciences
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HIROMACHI Sachiko
Department of Nursing Science, Gunma University College of Health Sciences
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FUTAWATARI Tamae
Department of Nursing, Gunma Prefectural College of Health Sciences
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ARAI Michiko
Department of Nursing Science, Gunma University College of Health Sciences
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Arai Michiko
Department Of Nursing College Of Health Sciences Gunma University
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Ito Yoshikazu
Department Of Nursing College Of Health Sciences Gunma University
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Ito Yoshikazu
Department Of Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Technology
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FUTAWATARI Tamae
Gunma Prefectural College of Health Sciences
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Hiromachi Sachiko
Department Of Nursing College Of Health Sciences Gunma University
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NAKAZATO Yoichi
Department of Pathology, Gunma University School of Medicine
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