A Cytoprotection of Rat Hepatocytes Mediated by the Intracellular Calcium(International Symposium of Maxillofacial & Oral Regenerative Biology in OKAYAMA 2005)

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The role of intracellular Ca^<2+> in CCl_4 hepatotoxicity in rats was clarified by measuring detailed changes in serum ALT values and intracellular Ca^<2+> after CCl_4 administration. Serum ALT activity clearly increased up to a peak value at 1 day after i.p. administration of CCl_4 at 0.2ml/kg, and then decreased to the control level after 3 days. Intracellular Ca^<2+> responded to CCl_4 intoxication with a biphasic increase. The first intracellular Ca^<2+> peak increased up to 5.6-fold the control level at 1 hour, and the second Ca^<2+> peak 6.5-fold at 3.5 days. The results showed that the first Ca^<2+> increase might be attributable to a signal arising from the extent of hepatic injury. The second Ca^<2+> increase might act to activate cellular protective functions. We discussed that sustained intracellular Ca^<2+> and S100A4 increases may be involved in autoprotection or adaptive cytoprotection, namely susceptibility against a toxication.