A Protective Function Against Radical Stress Mediated by the Intracellular Calcium in Rat Hepatocytes(International Symposium of Maxillofacial & Oral Regenerative Biology in OKAYAMA 2005)
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概要
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The role of intracellular Ca^<2+> in CCl_4 hepatotoxicity in rats was clarified by measuring detailed changes in serum ALT values and intracellular Ca^<2+> after CCl_4 administration. Intracellular Ca^<2+> responded to CCl_4 intoxication with a biphasic increase. The first intracellular Ca^<2+> peak increased up to 5.6-fold the control level at 1 hour, and the second Ca^<2+> peak 6.5-fold at 3.5 days. We further examined the effects of drugs on serum ALT activity and intracellular Ca^<2+> in rats administered at 1 hour prior to or 3 hours after CCl_4 administration. The results showed that the first Ca^<2+> increase might be attributable to a signal arising from the extent of hepatic injury. The second Ca^<2+> increase might act to activate cellular protective functions. We discussed that sustained intracellular Ca^<2+> increases may be involved in autoprotection, namely susceptibility against a toxication.
著者
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Ueda Yukari
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Taira Zenei
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Taira Zenei
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Taira Zenei
Faculty Of Pharmaceutical Sciences The University Of Tokushima:faculty Of Home Economics Shikoku Wom
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Ueda Yukari
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Yabe Kazunori
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
関連論文
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