口腔Bacteroidesと歯周組織のサイトカインネットワーク : 歯周病の機序試論

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Oral Bacteroides species represented by Bacteroides (Porphyromonas) gingivalis and Bacteroides intermedius (Prevotella intermedia), which are predominant in subgingival plaques of adult periodontitis patients and are possible periodontopathic bacteria, possess bioactive materials such as cytoplasmic membranes, peptidoglycans, outer membrane proteins, lipopolysaccharides (LPS), capsules, and fimbriae on their cell surfaces. These materials may modulate the cytokine network in periodontal tissues and induced excessive production of cytokines. Some cytokines are involed in inflammatory as well as immunological responses, and are designated as inflammatory cytokines. Among the inflammatory cytokines, interleukin (IL) I has been the most extensively studied, and its existence in periodontal tissues of periodontitis patients and its etiological correlation with periodontitis have been well demonstrated. We found that oral Bacteroides LPS, but not other LPS, induced cell-associated IL-1 α and cell-free IL-1β and IL-6 in normal human gingival fibroblast cultures. The fibroblasts primed with some cytokines, including interferon (IFN)-β, IFN-γ and tumor necrosis factor, produced much higher cell-associated IL-1 α than the non-primed fibroblasts upen stimulation with Bacteroides LPS. The IL-1 is capable of inducing proliferation, matrice formation, and production various cytokines such as IL-1 itself, IL-6,IL-8,colony stimulating factors in fibroblasts themselves and other cells in periodontal tissues. These cytokines in turn augment the inflammatory responses in periodontal tissues. This vicious cascade may be involved in the initiation and development of periodontal diseases characterized by localized chronic inflammation accompanying bone resorption.
鹿児島大学の論文
1991-03-26

口腔Bacteroidesと歯周組織のサイトカインネットワーク : 歯周病の機序試論

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