ラット口蓋癌由来培養細胞の生物学的性状解明

概要

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4-nitroquinoline N-oxide (4NQO) administrated rats have high occurrence of palatal squamous cell carcinoma (SCO, which almost always accompanies resorption of the jaw bone. We have developed a cell strain (11/8F) from a rat palatal SCC induced by 4NQO administration. The cultured cells are polygonal or round in shape, and they exhibited cobble-stone growth pattern. Immunocytochemically, 11/8F cells were positive with four anti-cytokeratin antibodies; AE1, AE3, CAM5.2, and KL1. It is also found that an immunoreactivity for parathyroid hormone-related protein (PTHrP), which is closely related to cancerous bone resorption. In addition, expression of PTHrP mRNA were identified. The cell strain 11/8F, exhibiting characters as noted above, might permit establshing an experimental model to clarify mechanisms of bone destruction with oral SCC invasion.
奥羽大学の論文
2006-03-31