Search of the Infections Source of feline calicivirus in a Multicat Household

概要

論文の詳細を見る
A multicat household experienced an epidemic of feline calicivirus (FCV) infection. FCV was isolated from eight of 34 cats. We analyzed molecular evolution of isolated FCVs by a phylogenic tree. All the isolates belonged to the genogroup II, and their nucleotide sequences showed >94% identity. They were subdivided into six distinct clusters by phylogenetic analysis, and Ao198-1, the source of infection, was most closely related to Ao199-1, then Ao212-1, Ao210-1, Ao214-1, Ao213-1, Ao222-1 and Ao224-1 in this order. Sequence alignments of the isolates showed that the nonsynonymous substitution/total number of nucleotides ratio was <60% in the regions A, B, D conE and F, and >80% in the regions C and 5' and HVR of E. Our result suggested that the virus, while its transmission to the newborn cats, underwent frequent mutation especially at the regions C and E, suggesting these regions were most often involved in evolution of the FCV genome.
麻布大学の論文