Suppression of Feline Calicivirus Replication Using Small Interfering RNA Targeted to Its Polymerase Gene

スポンサーリンク

概要

• 論文の詳細を見る

• Feline calicivirus (FCV) is a pathogenic microorganism that causes upper respiratory diseases in cats. Recently, an FCV infection with a high mortality rate has been confirmed, and there is need to develop a treatment for cases of acute infection. We evaluated whether the replication of FCV could be prevented by RNA interference. For this study, we designed an siRNA targeted to the polymerase region of the strain FCV-B isolated from a cat that died after exhibiting neurological symptoms. Cells transfected with siR-pol dose-dependently suppressed the replication of FCV-B. siR-pol suppressed its replication by suppressing the target viral RNA.

• 日本防菌防黴学会の論文
• 2012-06-10

著者

• 原 元宣

  School Of Veterinary Medicine Azabu University

• 大江 香子

  School Of Veterinary Medicine Azabu University

• Sakai Sachi

  School Of Veterinary Medicine Azabu University

• Sato Atsuko

  Department Of Clinical Oncology Institute Of Development Aging And Cancer Tohoku University

• Hara Motonobu

  Department Of Microbiology Ii School Of Veterinary Medicine Azabu University

• Takahashi Toshikazu

  Department Of Pediatrics Takahashi Clinic Shinko Hospital

• Sakai Sachi

  Department Of Microbiology Ii School Of Veterinary Medicine Azabu University

• Sato Atsuko

  Department Of Microbiology Ii School Of Veterinary Medicine Azabu University

• TAHARAGUCHI SATOSHI

  Department of Microbiology II, School of Veterinary Medicine, Azabu University

• MATSUHIRO TAKAHISA

  Department of Microbiology II, School of Veterinary Medicine, Azabu University

• HARIMA HAYATO

  Department of Microbiology II, School of Veterinary Medicine, Azabu University

• OHE KYOKO

  Department of Microbiology II, School of Veterinary Medicine, Azabu University

• Taharaguchi Satoshi

  Department Of Microbiology Ii School Of Veterinary Medicine Azabu University

• Harima Hayato

  Department Of Microbiology Ii School Of Veterinary Medicine Azabu University

• TAKAHASHI TOSHIKAZU

  Department of Microbiology II, School of Veterinary Medicine, Azabu University

関連論文

• Phylogenetic analysis of feline calicivirus capsid gene in infected cats
• Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo
• Identification of Pink-Pigmented Bacteria Isolated from Environmental Water Samples and Their Biofilm Formation Abilities
• Characteristics of a Pink-Pigmented Bacterium Isolated from Biofilm in a Cooling Tower in Tokyo, Japan
• 歯科治療恐怖症へのアプローチの1例について
• Isolation and Identification of Methylobacterium Species from the Tap Water in Hospitals in Japan and Their Antibiotic Susceptibility
• Search of the Infections Source of feline calicivirus in a Multicat Household
• Inactivation of Legionella pneumophila from Whirlpool Bath Waters by Grapefruit (Citrus paradisi) Seed Extract
• SOCIAL IMAGES OF DENTISTRY AND DENTAL CARIES EXPERIENCE IN UNIVERSITY STUDENTS
• Identification of Legionella londiniensis isolated from hot spring water samples in Shizuoka, Japan, and cytotoxicity of isolates
• Powder infant formula milk contaminated with Enterobacter sakazakii
• Anti Pseudorabies Virus Activity of Kumazasa Extract
• Eleven-Year Follow Up of Bilateral Revision Total Hip Arthroplasty : A Case Report
• Curcumin analog GO-Y030 is a novel inhibitor of IKKβ that suppresses NF-κB signaling and induces apoptosis
• Contribution of autophagic cell death to p53-dependent cell death in human glioblastoma cell line SF126
• Prevalence of Feline Coronavirus Antibodies in Japanese Domestic Cats during the Past Decade
• Suppression of Feline Calicivirus Replication Using Small Interfering RNA Targeted to Its Polymerase Gene
• Tuft cells
• Efficacy and Safety of Insulin Aspart in Patients with Type 1 Diabetes Mellitus
• Borna Disease Virus Infection in Domestic Cats: Evaluation by RNA and Antibody Detection.

もっと見る 閉じる

スポンサーリンク