The Effects of Eicosapentaenoic Acid-Fortified Food on Inflammatory Markers in Healthy Subjects : A Randomized, Placebo-Controlled, Double-Blind Study

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概要

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• Epidemiological studies showed that habitual fish intakes were associated with lower blood inflammatory markers. In the present study the effects of a fish oil-containing food on inflammatory markers were investigated in healthy, mostly middle-aged subjects (59 men and 82 women) with normal to mildly elevated triglyceride levels. Study subjects were randomly allocated to two groups in a double-blind manner; one group ingested an eicosa-pentaenoic acid (EPA)-rich fish oil-fortified drink (0.60g EPA+0.26g docosahexaenoic acid/d, EPA group, n=68) for 12wk. The rest of the subjects took a placebo (control group, n=73). Plasma levels of high sensitivity C-reactive protein (hs-CRP) and soluble tumor necrosis factor-receptors 1 and 2 (sTNF-Rs 1 and 2) were measured at the start and end of intervention. EPA concentrations in the total RBC phospholipid fraction significantly increased by 79% in the EPA group at the end of the study, and they changed very little in the control group (+0.68%). The inflammatory markers did not change in either group. It is likely that fish oil does not change hs-CRP or sTNF-Rs 1 or 2 in subjects without active inflammation.

• 日本ビタミン学会の論文

著者

• Hamazaki Kei

  Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Unive

• Itomura Miho

  Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Unive

• Huan Mingming

  Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Unive

• Kitajima Isao

  Laboratory Medicine University Of Toyama School Of Medicine

• HAMAZAKI Tomohito

  Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, To

• FUJIOKA Shuntaro

  Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, Un

• NISHIZAWA Hiroto

  Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, Un

• SAWAZAKI Shigeki

  First Department of Internal Medicine, University of Toyama School of Medicine

• Hamazaki Tomohito

  Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Unive

• Hamazaki Tomohito

  Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Toyam

• Fujioka Shuntaro

  Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Unive

• Nishizawa Hiroto

  Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Unive

• Sawazaki Shigeki

  First Department Of Internal Medicine University Of Toyama School Of Medicine

• Sawazaki Shigeki

  First Department Of Internal Medicine School Of Medicine Toyama Medical And Pharmaceutical Universit

• Hamazaki Kei

  Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Unive

関連論文

• Dietary Supplementation with n-3 Polyunsaturated Fatty Acids Attenuates the Depression of Food-Motivated Behavior during Zymosan-Induced Peritonitis(Biochemistry)
• The Effects of Eicosapentaenoic Acid-Fortified Food on Inflammatory Markers in Healthy Subjects : A Randomized, Placebo-Controlled, Double-Blind Study
• Effect of Dietary Enrichment with n-3 Polyunsaturated Fatty Acids (PUFA) or n-9 PUFA on Arachidonate Metabolism in Vivo and Experimentally Induced Inflammation in Mice (Biochemistry/Molecular Biology)
• The Effect of Docosahexaenoic Acid on Plasma Catecholamine Concentrations and Glucose Tolerance during Long-Lasting Psychological Stress : A Double-Blind Placebo-Controlled Study

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