Dietary Supplementation with n-3 Polyunsaturated Fatty Acids Attenuates the Depression of Food-Motivated Behavior during Zymosan-Induced Peritonitis(Biochemistry)
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概要
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Peripheral inflammation is accompanied by neurobehavioral alterations such as depression of feeding, exploratory and sexual behaviors. Our previous investigation reported that dietary enrichment with n-3 polyunsaturated fatty acids (PUFA) attenuated the depression of food-motivated behavior and social exploration, but not endocrinological and metabolic disturbances in the mice with systemic inflammation induced by lipopolysaccharide (LPS). We here demonstrate that dietary n-3 PUFA also attenuate the reduction of food-motivated behavior during zymosan-induced peritonitis in mice without influencing plasma leakage into peritoneum and writhing response. Our results suggest that the common mechanism is involved in the attenuation of behavioral depression during systemic and local inflammation by dietary n-3 PUFA.
- 公益社団法人日本薬学会の論文
- 2005-07-01
著者
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Takenaka Mizuki
Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Toyam
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KANADA Satoko
Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, To
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HAMAZAKI Tomohito
Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, To
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WATANABE Shiro
Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, To
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Hamazaki Tomohito
Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Toyam
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Kanada Satoko
Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Toyam
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Watanabe Shiro
Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Toyam
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Watanabe Shiro
Division Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Toyam
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Hamazaki Tomohito
Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
関連論文
- Dietary Supplementation with n-3 Polyunsaturated Fatty Acids Attenuates the Depression of Food-Motivated Behavior during Zymosan-Induced Peritonitis(Biochemistry)
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