2 肥満(シンポジウム生活習慣病 : 臓器障害と治療のEBM,第609回新潟医学会)

概要

論文の詳細を見る
Obesity is one of the most common disorders in medical practice and among the most frustrating and difficult to manage. Obesity is defined as an excess of adipose tissue, resulting in body mass index greater than 25 in Japan. Upper body obesity (excess fat around the waist and flank) is a greater health hazard than lower body obesity (fat in the thigh and buttocks). Obesity is associated with significant increase in both morbidity and mortality. A great many disorders occur with greater frequency in obese people. Obese patients with increased abdominal circumference greater than 85cm in men and 90cm in women have a greater risk of association with multiple metabolic and structural disorders, including diabetes mellitus, hypertension, and hyperlipidemia; metabolic syndrome. Fatty liver is another problem of obesity. Fatty liver is caused by ethanol and nonalcohol. Steatosis is nearly universal in obese alcoholics and is a hallmark of metabolic syndrome. In addition to macrovesicular steatosis, histologic features may include pericellular fibrosis, focal infiltration by polymorphonuclear neutrophils and Mallory's hyaline, a picture indistinguishable from that of alcoholic hepatitis and referred to as nonalcoholic steatohepatitis (NASH).
新潟大学の論文
2005-11-10