膵腫瘍ラットにおける^<111>In-DTPA Octreotideと^<111>In-DOTATOCの生体内分布の比較(外科学)
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概要
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^<111>In-DTPA octreotide (DTPAOC)はソマトスタチンレセプター陽性腫瘍の検出のために長い間用いられてきた.この度,診断および治療の目的のために^<111>In-DOTA-Tyr3-octreotide(DOTATOC)が新しく開発された.本研究において,我々はラットにDTPAOCまたはDOTATOCを投与し,その生体内分布と腫瘍取り込み比率を比較した.12匹の膵腫瘍ラットを6匹ずつ2群に分け,それぞれの群に3.7mBqのDTPAOCまたはDOTATOCを投与後4時間目に安楽死し,様々な臓器の組織中濃度を測定した.さらに,別の12匹を用いて同様に37mBqのDTPAOCまたはDOTATOCを投与後,4,24および48時間日にスキャンし,薬剤の腫瘍内取り込み比率(T/N比率)を測定した.体内分布測定の結果,何れも放射性薬剤として高い腫瘍親和性を示したが,腫瘍における活性は腎臓と同様にDTPAOC群に比べてDOTATOC群で有意に高かった.また,投与後24時間目のDOTATOC群のT/N比率は,DTPAOC群より有意に高かった.結論として,これらの二剤は何れも高い腫瘍親和性を示したが,膵臓腫瘍ラットにおいてDOTATOCはDTPAOCより低いクリアランスを示すと判断された.
- 2006-04-25
著者
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Lin Yung-chang
台湾
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Lin Yung-chang
Department Of Veterinary Medicine National Chung-hsing University
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LIN Wan-Yu
Departments of Nuclear Medicine, Taichung Veterans General Hospital
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HUNG Guang-Uei
Department of Nuclear Medicine, Changhua Christian Hospital
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LIN Yung-Chang
Veterinary Medical Teaching Hospital
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Lin Y‐c
Chang Gung Memorial Hospital Taipei Twn
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LUO Tsai-Yueh
Isotope Application Division, Institute of Nuclear Energy Research
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HSIA Chien-Chung
Isotope Application Division, Institute of Nuclear Energy Research
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CHEN Shu-Ling
Isotope Application Division, Institute of Nuclear Energy Research
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CHEN Chun-Hsiung
Department of Veterinary Medicine, National Chung-Hsing University
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HO Yung-Jen
Department of Radiology, China Medical University Hospital
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Lin W.-y
台湾
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Chen Shu-ling
Isotope Application Division Institute Of Nuclear Energy Research
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Hung Guang-uei
Department Of Nuclear Medicine Changhua Christian Hospital
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Hsia Chien-chung
Isotope Application Division Institute Of Nuclear Energy Research
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Lin Y.-c
Department Of Veterinary Medicine National Chung-hsing University
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Ho Yung-jen
Department Of Radiology China Medical University Hospital
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Luo Tsai-yueh
Isotope Application Division Institute Of Nuclear Energy Research
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Lin Wan-yu
Department Of Marine Biotechnology And Resources National Sun Yat-sen University
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Chen Chun-hsiung
Department Of Veterinary Medicine National Chung-hsing University
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Lin Wan‐yu
Taichung Veterns General Hospital Taichung Twn
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Hung Guang‐uei
Changhua Christian Hospital Changhua Twn
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Luo Tsai-Yuhe
Isotope Application Division, Institute of Nuclear Energy Research
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