肺癌の放射線治療成績を左右する因子に関する臨床的研究

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Instead of many efforts to improve =e rate, lung cancer still shows the high inexorable mortality rate, Major obstacles to successful management in radiotherapy of lung cancer include 1) radiation pneumonitis ; 2) suppression of cell-mediated immunity ; 3) poor response to radiotherapy for large local tumor burden and diversified histological types. This report refers to those factors influencing prognosis. Radiation pneumonitis can be pointed out in over 90% of patients treated with radiotherapy on chest plain films and repeated CT scans give more detailed information than conventional radiograms. To add to these results, pathological analysis are also made on pre-operative irradiated lung. The immune responses of patients with lung cancer undergoing therapeutic irradiation are evaluated on each patient before and after 40 Gy of irradiation. Absolute lymphocyte count, PPD skin test, PHA skin test, and in vitro lymphocyte blastoid transformation test with PHA are depressed as the increment of irradiated dose. The valid combination of these parameters well correlates patient's prognosis. The radiographic evaluation of primary response of radiotherapy and pathologic evaluation under the Hhboshi-Shimosato's classification of radiation effect are performed. Adenocarcinomas show poor response. The radiographic primary response does not well correlate pathological effect. There is no local failure case in Ohboshi-Shimosato's classification III or .more and in post surgical N (-) group. It is projected that much useful research can be conducted during this decade using clinical tools now aveilable.
神戸大学の論文

肺癌の放射線治療成績を左右する因子に関する臨床的研究

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