Effects of 1, 9-Dideoxy Forskolin on Delayed Rectifier Potassium Current of Bullfrog Dorsal Root Ganglion Cells
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概要
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Whole-cell voltage-clamp recordings were made from cultured bullfrog dorsal root ganglion cells to examine the channel blocking activity of 20μM of 1, 9-dideoxy forskolin (d-FSK) on the delayed rectifier potassium current. The drug reduced the maximum amplitude of the current (10-20nA at +65mV) by 40-80%. However, the voltages for 50%-activation (≈ -12mV) and for 50%-inactivation (≈ -37mV) remained unaffected by d-FSK. These results indicate that the channel block by d-FSK occurs in a voltage-independent manner.
- 東海大学の論文
著者
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Tokimasa Takayuki
Department Of Physiology School Of Medicine Tokai University
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Tokimasa Takayuki
Department Of Physiology
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