Critical Period of Brain Development in Learning Caused by Lead Exposure in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Three groups of rats (group a, b and c) with high and stable avoidance, and low variability, named Tokai High Avoiders (THA) strain, (a) via placenta from the 13th day of gestation, through maternal milk during lactation and per os after weaning (group Pb-gestation), (b) through maternal milk during lactation and per os after weaning (group Pb-birth), (c) per os after wearing (group Pbweaning). The pre-and postnatal lead exposure induced apparent delays in speed of learning acquisition and broke the uniformity in avoidance rate in both males and females. Postnatal lead exposure caused slight delays in speed of learning acquisition in males alone. In the post wearing period defect in learning due to lead exposure could be observed in both males and females. No apparent difference was present in the development of pups among the lead exposed groups and control. From these results, it could be deduced that the most sensitive period of brain development in learning affected by lead exposure was the pre-and early postnatal period in the rat.
- 東海大学の論文
著者
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Misawa Tetsuo
Department of Laboratory Medicine, Yamagata University School of Medicine
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SHIGETA Sadayoshi
Department of Environmental Medicine and Occupational Health, School of Medicine, Tokai University
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Misawa Tetsuo
Department Of Environmental Medicine And Occupational Health Tokai University School Of Medicine
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Misawa T
Tokai Univ. School Of Medicine Kanagawa Jpn
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Misawa Tetsuo
Department Of Environmental Health Tokai University School Of Medicine
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MIYAKE Kumiko
Department of Pediatrics, St. Luke's International Hospital
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Miyake Kumiko
Department Of Environmental Medicine And Occupational Health Tokai University School Of Medicine
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Shigeta Sadayoshi
Department Of Environmental Health Tokai University School Of Medicine
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Shigeta Sadayoshi
Tokai Univ. School Of Medicine Kanagawa Jpn
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Misawa Tetsuo
Department Of Environment Medicine And Occupational Health Tokai University School Of Medicine
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