Effects of Adenosine on Cholinergic Transmission in Mammalian Vesical Parasympathetic Ganglia
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概要
- 論文の詳細を見る
Intracellular recordings were made from mammalian vesical parasympathetic ganglia. A fast excitatory postsynaptic potential (EPSP) was abolished by hexamethonium (200 μM) in rabbit and feline ganglia. A slow inhibitory postsynaptic potential (IPSP) and a following slow EPSP were abolished by atropine (1 μM) in the feline ganglia. Bath application of adenosine (300 μM) depressed the amplitude of nicotinic fast EPSP by 48±4% in the rabbit ganglia. The action of adenosine was dose-dependent An antagonist of A1-purinoceptors, 8-cyclopentyltheophylline (1-10μM), inhibited the adenosine-induced depression but not the amplitude of fast EPSP. Adenosine (2-3mM) did not significantly affect either the muscarinic slow IPSP, or the slow EPSP, in the feline ganglia. Adenosine also caused a hyperpolarization (1-5 mV) in 40% of the rabbit neurons and 66% of the feline neurons. However a purinergic IPSP was not recorded from either species. These data suggest diverse actions of adenosine in modulating cholinergic transmission in rabbit and feline vesical ganglia.
- 東海大学の論文
著者
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NISHIMURA Toshihiko
Department of Surgery, Sendai Kosei Hospital
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Nishimura Toshihiko
Division Of Nephrology Department Of Internal Medicine Tokai University Oiso Hospital
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Nishimura Toshihiko
Department Of Neurosurgery Fuchu Metropolitan Hospital
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