Immunodeficiency after Allogeneic Bone Marrow Transplantation in Man : The Role of Antigen Presenting Cells

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概要

• 論文の詳細を見る

• We investigated the proliferative response of donor T cells to phytohemagglutinin (PHA) presented by donor non-T cells in 7 patients after allogeneic bone marrow transplantation. Compared with the cellular response in the healthy marrow donors, T cell proliferation was found to be deficient in every recipient, from 130 to 739 days after grafting. Results of cell mixing experiments showed that the non-T cells of the patients were as capable as healthy donor non-T cells in presenting PHA to normal donor T cells. However, T cells from patients did not proliferate after substituting donor non-T cells for non-T cells from patients. This inability of T cells to proliferate was most likely the result of ineffective interactions among T cell subsets in patients after allogeneic bone marrow transplantation.

• 東海大学の論文

著者

• Moller J

  Department Of Internal Medicine B University Hospital In Copenhagen At Ferderiksberg

• Jacobsen Niels

  Department Of Internal Medicine B University Hospital In Copenhagen At Frederiksberg:department Of H

• Jacobsen N

  Department Of Internal Medicine B University Hospital In Copenhagen At Frederiksberg:department Of H

• MφLLER Jarl

  Department of Internal Medicine B, University Hospital in Copenhagen at Ferderiksberg

• DICKMEISS Ebbe

  Department of Clinical Immunology, University Hospital Rigshospitalet

• SVEJGAARD Arne

  Department of Clinical Immunology, University Hospital Rigshospitalet

• Mφller Jarl

  Department Of Internal Medicine B University Hospital In Copenhagen At Ferderiksberg

• Dickmeiss E

  Department Of Clinical Immunology University Hospital Rigshospitalet

• Dickmeiss Ebbe

  Department Of Clinical Immunology State University Hospital (rigshospitalet)

• Svejgaard A

  Department Of Clinical Immunology University Hospital Rigshospitalet

• Jacobsen Niels

  Department Of Clinical Immunology University Hospital Rigshospitalet

関連論文

• Cytotoxic T Cell activity after HLA-mismatch Bone Marrow Transplantation
• Immunephenotyping of T Lymphocytes from Patients after Allogeneic Bone Marrow Transplantation
• Immunodeficiency after Allogeneic Bone Marrow Transplantation in Man : The Role of Antigen Presenting Cells
• Intravenous Hyperimmune Globulin Prophylaxis against Cytomegalovirus Interstitial Pneumonitis after Allogenic Bone Marrow Transplantation
• Immunology of the Human Immunodeficiency Virus Infection
• The Immunodeficiency After Allogeneic Bone Marrow Transplantation in Man : Role of Cytokines

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