Evaluation of Aminophylline Suppositories Prepared in a Hospital Pharmacy
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概要
- 論文の詳細を見る
Physical and chemical stability of suppositories containing aminophylline and various bases prepared in our hospital pharmacy was investigated. Ethylenediamine in aminophylline decreased, the melting points of the suppositories rose, and the disintegration and liquefaction times were prolonged in suppositories with Witepsol base when stored at room temperature. Thin-layer chromatography produced evidence supporting the assumption that ethylenediamine may react with some Witepsol constituents to form an acid amide linkage. However, the suppositories were stable at lower temperatures. Suppositories prepared with PEG base were found to be satisfactorily stable at room temperature.
- 東海大学の論文
著者
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TOGAWA Kunihito
Department of Pharmacy, Tokai University Hospital
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KUBOTA Akie
Department of Pharmacy, Tokai University Hospital
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MIZUSHIMA Noriko
Department of Pharmacy, Tokai University Hospital
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Kubota Akie
Department Of Pharmacy Tokai University Hospital
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Togawa Kunihito
Department Of Ophthalmology School Of Medicine Tokai University
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FUJII Tadao
Department of Pharmacy, Tokai University Hospital
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Fujii Tadao
Department Of Pharmacy Tokai University Hospital
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Mizushima Noriko
Department Of Pharmacy Tokai University Hospital
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