Extracellular ATP both inhibits and facilitates calcium channel currents in acutely dissociated rat nucleus tractus solitarius
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概要
- 論文の詳細を見る
The postsynaptic actions of exogenously applied adenosine 5'-triphosphate (ATP) were investigated in nucleus tractus solitarius (NTS) of the rat. Whole cell patch-clamp recordings were used to examine the regulation of voltage-dependent Ca^<2+> channels (VDCCs) currents (I_<Ca>) by ATP in freshly dissociated NTS. Application of ATP inhibited I_<Ca> from -905pA to -741pA. In addition to this inhibition, application of ATP facilitated I_<Ca> from -941pA to -1,094pA in other neurons. The data presented here demonstrate for the first time that ATP has both inhibitory and facilitative effects on I_<Ca> in NTS. It can be considered that ATP acts as a neurotransmitter in the NTS by having multiple regulatory effects on VDCCs.
- 東京歯科大学の論文
著者
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Endoh T
Department Of Electrical And Electronic Engineering Faculty Of Engineering Muroran Institute Of Tech
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Endoh Takayuki
Department Of Physiology Tokyo Dental College
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