可溶化型T細胞レセプター

概要

論文の詳細を見る
Cellular immunity is mediated by the interaction of a T cell receptor (TCR) with a peptide presented within the context of a major histocompatibility complex (MHC) molecule. In order to clarify the detailed mechanism of allergy and autoimmunity, it is critical to define the system of TCR recognition to its ligand, antigenic peptide and MHC complex (pMHC) at the molecular level. Analyses of the physico-chemical properties and structure of TCR interacting with pMHC are necessary to answer this question. Since TCR is a membrane-bound protein, it is difficult to apply these analyses to intact TCR molecules. Therefore a soluble type of TCR (sTCR) is necessary for this purpose. sTCR is also expected to be useful to identify the antigen presenting region in intestine or thereabouts for orally administrated food allergen. From a clinical viewpoint, sTCR would be applicable to treatment of diseases caused by pathogenic T cell responses specific for a certain antigen, such as autoimmune diseases and allergies. In this review, we will introduce and discuss the recent topics including our study of sTCR.
昭和女子大学の論文
2004-12-01