富化γ-アミノ酪酸経口投与における更年期障害及び初老期精神障害に対する効果 : 農林水産省共同研究(文化編)

概要

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A placebo-controlled, double-blind, cross-over triak was carried in 20 out-patients with climacteric and senile disorders to investigate the efficacy and tolerance of oral treatment with accumulated γ-aminobutyric acid. One group of patients received accumulated γ-aminobutyric acid and the other group placebo, three times daily over a period of 8 weeks. After the 8 weeks period group were reversed. Efficacy was tested by Kupperman's score before and after each treatment. As responders to treatment were considered patients with a reduction of at least 1 point in this score index, together with a positive overall judgement by the doctor. A significant decrease in the index was observed for accumulated γ-aminobutyric acid compared to placebo. The responder rate was 40% with accumulated γ-aminobutyric acid and only 15% with placebo. Clinical and biological tolerance were excellent with both treatments, and no definitely treatment-related complaints were recorded. It is suggested that oral treatment with accumulated γ-aminobutyric acid should be considered as basic nutritional care for the management of climacteric and senile mental disorders.
1998-09-30