[総説] キノロン系抗菌剤によるインスリン分泌促進作用のメカニズム

概要

論文の詳細を見る
Fluorinated quinolones are used for the treatment of a wide variety of infectious diseases. Recently these drugs were reported to induce hypoglycemia in geriatic patients. To elucidate the mechanism(s) of the hypoglycemia, we investigated the effects of various quinolone antibiotics on insulin release using rat pancreatic islets. In the presence of 10mM glucose, ciprofloxacin, enoxacin, lomefloxacin (LFLX), pipemidic acid, sparfloxacin, or tosufloxacin augmented insulin release in a dose-dependent manner. LFLX shifted the dose-response curve of glucose-induced insulin release to the left without altering the maximal response. At 10mM glucose, LFLX increased insulin release augmented by forskolin or 12-O-tetradecanoyl phorbol-13-acetate but not by raising the K^+ concentration from 6 to 25mM. Verapamil or diazoxide antagonized the insulinotropic effect of LFLX. These data suggest that quinolone antibiotics may cause hypoglycemia by increasing insulin release via an increase in cytosolic Ca^<2+> concentration following blockade of ATP-sensitive K^+ channels.
愛知学院大学の論文
2000-12-20