動物の生理作用に及ぼすメチル基供与体投与の影響について : I.シロネズミの脂肪代謝ならびに尿中N^1-メチルニコチンアミドの排泄に及ぼすコリン投与の作用

概要

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One group of rats were fed on the low protein diets which contain 10, 20 and 40 percent of soybean oil and 2, 4 and 6 g of choline per kg of diet for three weeks. Other group of rats were fed on the diets which contain the same ingredients but were devoid of choline for the same period. After experimental feeding all individuals were slaughtered and the amount of fat which was contained in the liver was estimated and those values were compared with each other. As a result, it was ascertaind that the value of fat content of the individuals of the group fed on the diets which were devoid of choline was always larger than that of individuals of the group fed on diets which were added with choline. In further experiments, the amount of choline contained in the liver of individuals of each group was estimated. But no difference was found between the two groups. Then other individuals of both groups were given nicotinamide and the excretion of urinary N^1-methylnicotinamide of these individuals were examined. As a result, it was certificated that urinary N^1-methylnicotinamide was detected in all the individuals of both groups, whether they were given choline or not. From these results, it is supposed that some amount of choline is always synthesized in the body of rats and that labile methyl derived from this synthesized choline is combined with nicotinamide to form urinary N^1-methylnicotinamide.
明治大学の論文