Solid Phase Synthesis of a Nonapeptide of Melittin

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概要

• 論文の詳細を見る

• The venom of the honey bee, Apris mellifica, is a strongly hemolytic polypeptide termed Melittin. It contains 26 amino acids, and the complete amino acid sequence of Melittin has recently been published^<(1-2)>. This paper reports the synthesis of a nonapeptide. Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu, of Melittin. An instrument, which can perform both automatically and manually all of the operation in the stepwise synthesis of peptide by the solid phase method, was constructed^<(3)>. The peptide was synthesized using manually the instrument. The peptide was purified by recrystallization and characterized by paper electrophoresis and amino acid analysis, and obtained in over all yield of 90%.

• 東北大学の論文

著者

• Seto Shuichi

  The Chemical Research Institute Of Non-aqueous Solutions

• MIURA Yoshiro

  The Chemical Research Institute of Non-Aqueous Solutions

• TOYAMA Michihiro

  The Chemical Research Institute of Non-Aqueous Solutions

関連論文

• Solid Phase Synthesis of a Nonapeptide of Melittin
• Syntheses of 2-Azido-5-nitrotropone and N-Troponyl Amino Acids

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