カルシニューリン阻害がラット骨格筋のsuperoxide dismutaseたんぱく発現および解糖系・酸化系酵素活性に及ぼす影響

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This study was designed to determine the effects of the administration of specific calcineurin inhibitor syslosporin A (C_sA) to reats for skeletal muscle superoxide dismutase (SOD) protein expression and glycolytic and oxidative enzyme activities. Male \wistar rats were divided into a CsA-treated group or a vehicle-treated group. CsA was subcurtaneously administrated into the rats at a rate of 25 mg kg body weight day for 10 sucessive days. The Cu/Zn-SOD proteins in slow-twich soleus muscle sifnificantly increased in the CsA-treated group but not in fast-twich extensor digitorum longrs (EDL) muscle. The pyruvate kinase activity in the soleus muscle also significantly increased in the CsA-treaed group buto not in the EDL muscle. The lactate dehydragenase activity in the solrus muscle tended to increase in the CsA-trease group while the defference did not reach significance. The Mn-SOD protein expression, citrate synthase activity or β-hydroxyacylCoA degydrogenase activity were not altered by CsA-treatment. These results seem to imply that calcineurim negatively regulates the Cu/Zn-SOD expression and glycolytic enzymes especially in slow-twich muscle.
久留米大学の論文