水溶性シクロデキストリンポリマーと界面活性剤の相互作用

概要

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The binding isotherms of nonionic surfactants onto water soluble polymer containing cyclodextrin (CD) were measured in aqueous solution at 25 °C. The nonionic surfactants used were polyoxyethylene nonylphenylether with different oxyethylene units. The binding affinities for nonionic surfactants decreased with increases in the length of oxyethylene units on the polymer. Molecular modeling studies were also performed in order to determine the preferred complex formation of cyclodextrin and nonionic surfactants. Molecular mechanics (MM) and molecular dynamics (MD) simulations served to investigate the molecular inclusion. The more energetically stable complexes by inclusion with CD calculated based on MM were obtained compared with CD and model compound of surfactant alone, respectively. The structural information about the preferred complex formation by inclusion from the MD calculations was also obtained, and the relative stability of comnlex and the involved molecular interactions were determined.
山口県立大学の論文
2005-03-25