Novel Therapeutic Approach Using siRNA to Reduce Plasama High Concentration of Lp(a)(Lipid Disorders 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

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概要

• 論文の詳細を見る
• 社団法人日本循環器学会の論文
• 2005-03-01

著者

• Tomita Naruya

  Division of Nephrology, Department of Internal Medicine, Kawasaki Mediccal School

• Morishita Ryuichi

  Division Of Gene Therapy Science Osaka University Graduate School Of Medicine

• Yamasaki Keita

  Osaka University Graduate School Of Medicine

• Tomita Naruya

  Division Of Nephrology Department Of Internal Medicine Kawasaki Medical School

• Tomita Naruya

  Division Of Clinical Gene Therapy

• Osako Mariana

  Division of Clinical Gene Therapy, Osaka University

• Osako Mariana

  Department Of Clinical Gene Therapy Osaka University Graduate School Of Medicine

• Osako Mariana

  Division Of Clinical Gene Therapy

• Tomita Naruya

  Osaka University Graduate School Of Medicine

• Koike Hiromi

  Department Of Geriatric Medicine Osaka University Graduate School Of Medicine

• Morishita Ryuichi

  Division Of Clinical Gene Therapy

• Osako Mariana

  Osaka University Graduate School Of Medicine

• Koike Hiromi

  Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine

• Kunugiza Yasuo

  Department Of Orthopaedic Surgery Osaka University Graduate School Of Medicine

• Izawa Keiko

  Osaka University Graduate School Of Medicine

• Izawa Keiko

  Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine

• Yamasaki Keita

  Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine

• Kunugiza Yasuo

  Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine

• Kurinami Hitomi

  Division Of Clinical Gene Therapy Graduate School Of Medicine Osaka University

• Kurinami Hitomi

  Department Of Geriatric Medicine

• Yamamoto Kei

  Department Of Geriatric Medicine Osaka University Medical School

• Morishita Ryuichi

  Department Cf Clinical Gene Therapy Graduate School Of Medicine Osaka University

関連論文

• Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats
• Genetic basis of hypertension for the development of tailored medicine
• PJ-184 Azelnidipine Prevent Renal Dysfunction in Dahl Salt-Sensitive Rats by Suppression of Sympathetic Nerve System(PJ031,Kidney/Renal Circulation/CKD 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• DPJ-016 Uremic Toxins and High Dietary Protein Intake Induce Endothelial Dysfunction in Rats with Chronic Kidney Disease(DPJ03,Kidney/Renal Circulation/CKD (H),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulatio
• Reactive oxygen species mediate compensatory glomerular hypertrophy in rat uninephrectomized kidney
• DPJ-016 Uremic Toxins and High Dietary Protein Intake Induce Endothelial Dysfunction in Rats with Chronic Kidney Disease(DPJ03,Kidney/Renal Circulation/CKD (H),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulatio
• Oral adsorbent AST-120 ameliorates endothelial dysfunction independent of renal function in rats with subtotal nephrectomy
• Blockade of serotonin 2A receptor improves glomerular endothelial function in rats with streptozotocin-induced diabetic nephropathy
• PJ-477 Visualization of glomerular hyperfiltration and microcirculation in the Streptozotocin-induced Diabetic rats(Diabetes/Obesity/Metabolic syndrome(12)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-344 Angiotensin Receptor Blocker Ameliorates Renovascular Injury and Oxidative Sress in Zucker Obese Rats Fed High-protein Diet(Kidney/Renal circulation(06)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
• 1 Association between Microalbuminuria and Endothelial Dysfunction(CKD (Chronic Kidney Disease) as a Risk Factor for Cardiovascular Disease (CVD),Topic 6 (TP-6) (H),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Olmesartan Ameliorates Progressive Glomerular Injury in Subtotal Nephrectomized Rats through Suppression of Superoxide Production
• DPJ-016 Uremic Toxins and High Dietary Protein Intake Induce Endothelial Dysfunction in Rats with Chronic Kidney Disease(DPJ03,Kidney/Renal Circulation/CKD (H),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulatio
• PJ-344 Angiotensin Receptor Blocker Ameliorates Renovascular Injury and Oxidative Sress in Zucker Obese Rats Fed High-protein Diet(Kidney/Renal circulation(06)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
• OE-071 A Genom-Wide Association Study of SNPs in the risk of Atherosclerosis Obliterans(Heart failure, clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• DPJ-013 Hepatocyte Growth Factor Attenuates TGF-β1 Angiotensin II Crosstalk by Down Regulation of Angiotensin II Type 1 Receptor through PTEN/Akt Pathway(DPJ03,Kidney/Renal Circulation/CKD (H),Digital Poster Session (Japanese),The 73rd Annual Scientific M
• Variation in OSBPL10 is associated with dyslipidemia
• Serum hepatocyte growth factor concentration is a specific marker of endothelial dysfunction in humans
• A weapon of endothelial cells for fighting vascular disease
• Association of Serum Oxidized Lipoprotein(a) Concentration with Coronary Artery Disease : Potential Role of Oxidized Lipoprotein(a) in the Vasucular Wall
• PJ-042 Pivotal Roles of CYLD (cylindromatosis) as a Deubiquitinating Enzyme in Vasculature(Atherosclerosis, basic(05)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Recognition of Tissue- and Subtype-Specific Modulation of Angiotension II Receptors Using Antibodies against AT_1 and AT_2 Receptors
• Symposium on The Etiology of Hypertension - Summerizing Studies in 20th Century -, Hypertension and Genes
• Lack of Association between the Hepatocyte Growth Factor Receptor, c-met, and the Anti-Apoptotic Action of Bag-1 in Endothelial Cells
• Recovery of Learning and Memory by Gene Therapy Using Hepatocyte Growth Factor Gene After Focal Cerebral Ishcemia in Rats(Gene Therapy/Genetic Engineering (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Pioglitazone Enhances the Antihypertensive and Renoprotective Effects of Candesartan in Zucker Obese Rats Fed a High-Protein Diet
• OJ-158 Olmesartan Improved Imbalance of NO and ROS Leading to Progression of Renal Damage in Rat 5/6 Remnant Model(Kidney / Renal circulation-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-156 A Calcium Channel Blocker, Azelnidipine, Ameliorates Angiotensin II-Induced Chronic Renal Damage(Kidney / Renal circulation-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Isohumulones Derived from Hops Ameliorate Renal Injury via an Anti-Oxidative Effect in Dahl Salt-Sensitive Rats
• OJ-109 Development of in Situ Method to Detect Reactive Oxygen Species and Nitric Oxide in Kidney(Kidney/Renal circulation-1 (H) OJ19,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Gene Polymorphism of Myospryn (Cardiomyopathy-Associated 5) Is Associated with Left Ventricular Wall Thickness in Patients with Hypertension
• Inhibitory Effect of Chimera Decoy Oligodeoxynucleotides (ODN) against Ets and NFκ B on the Progression of Rabbit Experimental Aortic Aneurysms (AAA)
• Gene Therapy for Abdominal Aortic Aneurysm (AAA) using Decoy Strategy against ets binding site
• Effect of E2F decoy on inhibitation of neointima formation in pig coronary arteries after balloon injury and stent implantation
• Transcription factor, ets-1, is a novel angiogenic molecule : Implication to ciene therapy to treat peripheral arterial disease
• Novel molecular intervention to treat abdominal aortic aneurysms (AAA) using chimera decoy oligodeoxynucleotides (ODN) against ets and NFkB binding sites
• Therapeutic Angiogenesis Induced by Endotherial Nitric Oxide Synthase Gene through VEGF Expression in Rat Hindlimb Ischemia Model
• Polymorphism of myospryn is associated with left ventricular diastolic dysfunction
• Increase in DNA Synthesis of Cardiac Myocytes by Transfection ofP53 and Rb Antisense : Possibility of Cardiac Myocytes Regeneration
• PJ-145 Periostin as a Novel Therapeutic Target for Heart Failure(Acute coronary syndrome, basic/clinical-7, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-024 New Mechanisms of an Angiotensin Receptor Blocker, Valsartan, on the Heart Failure through the Inhibition of Novel Anti-adhesion Molecule, Periostin(Heart failure, basic-2 (M) OJ4,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific
• Periostin as a Anti-adhesion Molecule Responsible for Ventricular Dilation(Heart Failure, Basic 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-003 Docking Protein Gab1 is Essential for HGF-dependent Endothelial Signaling and Angiogenesis after Hindlimb Ischemia(FRS1,New Molecules for Cardiovascular Regulation (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The J
• OE-206 Development of Ribbon Type NF-κ B Decoy Oligodeoxynucleotides(Genetics/Genetically engineered models/Gene therapy-1(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Nonviral HVJ (hemagglutinating virus of Japan) liposome-mediated retrograde gene transfer of human hepatocyte growth factor into rat nervous system promotes functional and histological recovery of the crushed nerve
• PE-062 Zyxin Progresses Epithelial-Mesenchymal Transition under the Control of Twist1 and Contributes to Endocardial Morphogenesis(PE011,Congenital Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation S
• IS023 Antisense Proliferating-cell Nuclear Antigen Oligonucleotide Attenuates Cardiac Allograft Arteriopathy
• PJ-086 Regression of Experimental Rabbit Aortic Aneurysm by The Treatment with Chimera Decoy Oligodeoxynucleotides (ODN) against ets and NFkB(Gene Therapy 1 (IHD) : PJ15)(Poster Session (Japanese))
• OJ-094 Delayed Post-ischemic Treatment with Fluvastatin Improved Learning and Memory Deficit After Stroke in Rats without affecting Infarction Volume(Cerebrovascular circulation / Stroke-1, The 71st Annual Scientific Meeting of the Japanese Circulation So
• PJ-654 Post-ischemic Administration of Fluvastatin Improves Cognitive Dysfunction in the Chronic Stage of Cerebral Infarction in Rat Model(Cerebrovascular circulation/Stroke-3 (H) PJ110,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meet
• PJ-652 Over-expression of HGF Improves Learning and Memory and Prevents Progressive Shrinkage of Thalamus in the Chronic Stage of Cerebral Infarction(Cerebrovascular circulation/Stroke-3 (H) PJ110,Poster Session (Japanese),The 70th Anniversary Annual Scie
• Transcription factor decoy oligonucleotide-based therapeutic strategy for renal disease
• PJ-740 Hepatocyte Growth Factor (HGF), but not Vascular Endothelial Growth Factor (VEGF), Attenuated Ang II-induced EC Senescence by Inhibiting PIP3/rac1 Activity(PJ124,Peripheral Cirulation/Vascular Disease (Therapy) 4 (H),Poster Session (Japanese),The 7
• OJ-060 Hepatocyte Growth Factor Attenuate Ang II-induced Inflammation and Proliferation of Smooth Muscle Cell through EGF Receptor Degradation(OJ10,Atherosclerosis, Basic (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanes
• PJ-686 Hepatocyte Growth Factor Can Attenuate Senescense of EPC through Anti-oxidative Stress Effect(Peripheral circulation/Vascular disease-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Application of Decoy Oligodeoxynucleotides for Arthritis
• 3 Functional Analysis of Novel Antimicrobial Peptide, AG (Angiogenic Peptide)-30, with Angiongenic Property, toward Clinical Application(The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Hepatocyte Growth Factor(HGF) as a Potential Index of Severity of Hypertension
• IS033 UP-REGULATION OF KEY TRANSCRIPTIONAL FACTOR FOR ANGIOGENESIS, ETS, AND INDUCTION OF ANGIOGENESIS BY IN VIVO GENE TRANSFER OF HUMAN HEPATOCYTE GROWTH FACTOR (HGF) INTO MYOCARDIUM
• IS028 GENE THERAPY OF RESTENOSIS BY IN VIVO GENE TRANSFER OF HUMAN HEPATOCYTE GROWTH FACTOR (HGF) THROUGH THE ACCELATION OF RE-ENDOTHELIALIZATION
• Contribution of a Vascular Modulator, Hepatocyte Growth factor (HGF), to the Pathogenesis of Cardiovascular Disease
• IS053 ANTI-APOPTOTIC ACTION OF HEPATOCYTE GROWTH FACTOR ON HUMAN AORTIC ENDOTHELIAL CELLS
• Potential Role of a Novel Vascular Modulator, Hepatocyte Growth Factor (HGF), in Cardiovascular Disease: Characterization and Regulation of Local HGF System
• PE-275 A Novel Strategy of the Gene Therapy for PAD Using Small RNA Interference of Cold Shock Domain Protein A(PE046,Atherosclerosis (Basic, Clinical/Diagnosis) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation
• 2 Estrogen Decreases the Activation of RANK-RANKL System in Vascular Calcification(Young Investigator's Award for International Students Finalists Lecture (YIA International),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-250 Cold shock domain protein A, novel regulator of angiogenesis in heart.(Coronary circulation, basic/clinical(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-185 Topical application of novel angiogenic peptide, AG-30, in wound healing model(Growth factor/Cytokine(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-040 FHL-2 Expresses in Endothelial Cell and Suppresses VEGF-induced Angiogenesis Via Sphingosine Kinase-1(Arrhythmia, diagnosis/Pathophysiology/EPS(01)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society
• OJ-195 Pivotal Roles of Deubiquitinating Enzymes UCHL1, HAUSP, and CYLD in Vasculature as an Anti-proliferative and Anti-inflammatory Effect(Atherosclerosis, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Adipose Tissue-Derived Stromal Cells as a Novel Option for Regenerative Cell Therapy
• PJ-752 A Novel Model of Vasculogenesis From ES Cells for Vascular Research and Regenerative Medicine(Development and differentiation-4 (M) PJ129,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Gene therapy for ischemic brain disease with special reference to vascular dementia
• PJ-709 Amyloid β 1-40 Disrupts Vascular Regeneration through the Inhibition of Endothelial Akt signaling(Regeneration (angionenesis/myocardial regeneration)-7 (M) PJ119,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
• PJ-477 A Therapeutic Strategy to Treat Brain Ischemia : Over-expression of Hepatocyte Growth Factor Gene Reduced Ischemic Injury in Rat Model(Cerebrovascular Circulation/Stroke 1 (H) : PJ80)(Poster Session (Japanese))
• PJ-345 Hepatocyte Growth Factor Attenuates Angiotensin II Induced Renal Fibrosis through TGF-B Suppression by Anoikis of Myofibroblasts(Kidney/Renal circulation(06)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation
• OJ-125 HGF,but not VEGF, Attenuated Angiotensin II-induced Senescence in EPC through Anti-Oxidative Stress Effect by Inhibiting Rac1 Activation.(Regeneration(angiogenesis / myocardial regeneration)(02)(M),Oral Presentation (Japanese),The 72nd Annual Scien
• PJ-762 Requirement of HIF-1a Signaling on the Expression of Nkx2.5 for Normal Heart Developement in Xenopus(Development and differentiation-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-188 Angiogenic and Anti-fibrotic Actions of Hepatocyte Growth Factor Improve Cardiac Dysfunction in Porcine Ischemic Cardiomyopathy(Genetics/Genetically engineered models/Gene therapy-3 (M) PJ32,Poster Session (Japanese),The 70th Anniversary Annual Sci
• PJ-098 Ubiquitin C-terminal Hydroxylase L1 (UCHL1), the Causative Genes of Inherited Parkinson's Disease, Has an Anti-inflammatory Action in Endothelial Cells(Molecular biology, vascular-3 (H) PJ17,Poster Session (Japanese),The 70th Anniversary Annual Sci
• PE-114 Angiotensin II Blocker, Valsartan, Supresses the Development of Experimental Abdominal Aortic Aneurysm in Rats(Peripheral circulation/Vascular disease(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
• Aging of Blood Vessels
• PJ-691 Inhibition of Development of Experimental Aortic Abdominal Aneurysm in Rat Model by Atorvastatin through Inhibition of Macrophage Migration(Peripheral circulation/Vascular disease-6, The 71st Annual Scientific Meeting of the Japanese Circulation So
• PE-543 Inhibiton of Experimental Aortic Abdominal Aneurysm by Angiotensin Receptor Blocker, Valsartan(Peripheral circulation/Vascular disease-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Two Years Follow-up of Clinical Trial of Human Gene Therapy for Peripheral Arterial Disease Using Hepatocyte Growth Factor Gene Transfer(Peripheral Circulation/Vascular Disease (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Clinical Trial of Human Gene Therapy Using Hepatocyte Growth Factor Gene Transfer(Translational Research in Cardiovascular Disease, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-013 Long Term Evaluation of Clinical Trial of Human Gene Therapy for Peripheral Arterial Disease Using Hepatocyte Growth Factor Gene Transfer(Angiogenesis and Regeneration Medicine in Cardiovascular Medicine (M) : FRS3)(Featured Research Session (Engl
• Increase in Peripheral Blood Flow by Intravenous Administration of Prostaglandin E1 in Patients with Peripheral Arterial Disease, Accompanied by Up-Regulation of Hepatocyte Growth Factor
• Inhibition of Restenosis by Beraprost Sodium (a Prostaglandin 12 Analogue) in the Porcine Coronary Artery after Angioplasty
• Results of Safety from Human Clinical Gene Therapy Using HGF (TREAT-HGF)
• Long Term Evaluation of Results from the First Stage in the Clinical Trial of Gene Therapy for Peripheral Arterial Disease
• Clinical Results of TREAT-HGF (Japan Trial to Treat Peripheral Arterial Disease by Therapeutic Angiogenesis Using Hepatocyte Growth Factor Gene Transfer)
• Evaluation of utility of prostagrandin E1 in the patients with ASO : Protective effect on endothelial function through up-regulation of HGF
• No increase in human HGF concentration in the patients transfected with human HGF plasmid : preliminary clinical results from TREAT-HGF
• PJ-341 Acceleration of wound healing by combination gene transfer of Hepatocyte Growth Factor and Prostacyclin Synthase with Shima Jet(Peripheral Circulation/Vascular Disease 3(H) : PJ57)(Poster Session (Japanese))
• Novel Therapeutic Approach Using siRNA to Reduce Plasama High Concentration of Lp(a)(Lipid Disorders 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Development of a Novel Ribbon-type Decoy Oligonucleotides to Treat Renal Damages Induced by Hypertension and Diabetes(Kidney/Renal Circulation 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-558 Improvement of Glomerulosclerosis by Aging in ACE-deficient Mouse(Kidney/Renal circulation-4 (H) PJ94,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-091 Improvement of Diabetic Neuropathy by HGF Gene Transfer(Gene Therapy 1 (IHD) : PJ15)(Poster Session (Japanese))
• PJ-089 Potential of Novel Ribbon-type E2F Decoy in vivo Neointimal Hyperplasia(Gene Therapy 1 (IHD) : PJ15)(Poster Session (Japanese))
• OJ-529 Ribozyme Oligonucleotides Against TGF-Beta Transferred by Ultrasound Inhibited the Progression of Diseases in Anti-Thy1 Model(Kidney/Renal Circulation 3 (H) : OJ65)(Oral Presentation (Japanese))

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