Transplantation of Dermal Multipotent Cells Promotes the Hematopoietic Recovery in Sublethally Irradiated Rats

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概要

• 論文の詳細を見る

• Our previous study indicated that dermal multipotent cells with the differentiation capacity to form cells with the phenotypic properties of osteocytes, adipocytes, chondrocytes, and neurons in specific inducing media could be isolated from the enzymatically dissociated dermal cells of newborn rats by their adherence to culture dish plastic. We have also observed that the systemic transplantation of dermal multipotent cells could not repopulate the hematopoietic system in lethally irradiated rats. In this paper, we found that a transplantation of plastic-adherent dermal multipotent cells into sublethally irradiated rats led to a significant increase of white blood cells in peripheral blood, nucleated cells, CFU-GM, and CFU-F colonies in bone marrow. FISH analysis, using a Y-chromosome specific probe, showed that dermal multipotent cells could engraft into bone marrow in recipients. Flow cytometry (FACS) analysis also showed that the proportion of CD2 and CD25 positive lymphocytes in peripheral blood did not change significantly in two weeks after transplantation. By these results, we infer that dermal multipotent cells may represent an alternative origin of mesenchymal stem cells to restore marrow microenvironment and promote the survival, engraftment, and proliferation of hematopoietic cells.

• 日本放射線影響学会の論文

著者

• Ran Xin-ze

  State Key Laboratory Of Trauma Burns And Combined Injury Institute Of Combined Injury Of Pla College

• Ran Xin

  Institute Of Combine Injury School Of Preventive Medicine State Key Laboratory Of Trauma Burns And C

• Su Yong-ping

  State Key Laboratory Of Trauma Burns And Combined Injury Institute Of Combined Injury Of Pla College

• Su Yong-ping

  Institute Of Combined Injury School Of Military Preventive Medicine State Key Laboratory Of Trauma B

• Su Yong

  Institute Of Combine Injury School Of Preventive Medicine State Key Laboratory Of Trauma Burns And C

• Cheng Tian

  Institute Of Combine Injury School Of Preventive Medicine State Key Laboratory Of Trauma Burns And C

• Cheng Tian-min

  Institute Of Combine Injury School Of Preventive Medicine Third Military Medical University

• SHI Chun

  Institute of Combine Injury, School of Preventive Medicine, State Key Laboratory of Trauma, Burns an

• MAI Yue

  Institute of Combine Injury, School of Preventive Medicine, State Key Laboratory of Trauma, Burns an

• QU Ji

  Institute of Combine Injury, School of Preventive Medicine, State Key Laboratory of Trauma, Burns an

• Qu Ji

  Institute Of Combine Injury School Of Preventive Medicine State Key Laboratory Of Trauma Burns And C

• Mai Yue

  Institute Of Combine Injury School Of Preventive Medicine State Key Laboratory Of Trauma Burns And C

• Shi Chun

  Institute Of Combine Injury School Of Preventive Medicine State Key Laboratory Of Trauma Burns And C

• Shi Chun-meng

  Institute Of Combine Injury School Of Preventive Medicine Third Military Medical University

関連論文

• Effect of hBD2 Genetically Modified Dermal Multipotent Stem Cells on Repair of Infected Irradiated Wounds
• Protective Effect of Atorvastatin on Radiation-induced Vascular Endothelial Cell Injury In Vitro
• Transplantation of Dermal Multipotent Cells Promotes the Hematopoietic Recovery in Sublethally Irradiated Rats
• CXCR4 Gene Transfer Enhances The Distribution of Dermal Multipotent Stem Cells to Bone Marrow in Sublethally Irradiated Rats
• Crucial Role of SDF-1/CXCR4 Interaction in the Recruitment of Transplanted Dermal Multipotent Cells to Sublethally Irradiated Bone Marrow
• Effects of the Nerve Growth Factor on the Survival and Wound Healing in Mice with Combined Radiation and Wound Injury
• Estimation of the Genetic Risks of Exposure to Ionizing Radiation in Humans : Current Status and Emerging Perspectives

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