Effects of the Nerve Growth Factor on the Survival and Wound Healing in Mice with Combined Radiation and Wound Injury

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概要

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• High dose of ionizing radiation could cause bone-marrow aplasia and delay wound healing. Nerve growth factor (NGF) has been demonstrated to play roles in wound healing and to affect the functional activities of mature immune and hematopoietic cells. In this study, we investigated the effects of NGF on survival and wound healing in mice with combined radiation and wound injury. Immunohistochemical analysis indicated that the expression of NGF decreased significantly at postwounding days 3, 5, 7, 10 and 14 in wounded tissues combined with total body irradiation of 5 Gy. NGF significantly increased the survival and migration of skin fibroblasts with the irradiation of 15 Gy in in vitro experiments. Intraperitoneal and topical applications of NGF increased the survival rate, peripheral white blood cells and bone-marrow nucleated cells; they also promoted wound healing and increased the cell number of fibroblasts and blood capillaries in granulation tissues. These results showed evidence that NGF could increase wound healing and promote survival in irradiated animals. This dual effect of NGF may provide a new tool for the treatment of radiation-combined injuries.

• 日本放射線影響学会の論文

著者

• SHI Chun-Meng

  Institute of combined injury, State Key Laboratory of Trauma, Burns and combined injury, School of M

• CHENG Tian-Min

  Institute of combined injury, State Key Laboratory of Trauma, Burns and combined injury, School of M

• Cheng Tian-min

  Institute Of Combined Injury State Key Laboratory Of Trauma Burns And Combined Injury School Of Mili

• Cheng Tian-min

  Institute Of Combine Injury School Of Preventive Medicine Third Military Medical University

• QU JI-FU

  Institute of Combine Injury, School of Preventive Medicine, Third Military Medical University

• Qu Ji-fu

  Institute Of Combine Injury School Of Preventive Medicine Third Military Medical University

• Shi Chun-men

  Institute Of Combined Injury State Key Laboratory Of Trauma Burns And Combined Injury School Of Mili

• Shi Chun-meng

  Institute Of Combine Injury School Of Preventive Medicine Third Military Medical University

関連論文

• Effect of hBD2 Genetically Modified Dermal Multipotent Stem Cells on Repair of Infected Irradiated Wounds
• Transplantation of Dermal Multipotent Cells Promotes the Hematopoietic Recovery in Sublethally Irradiated Rats
• CXCR4 Gene Transfer Enhances The Distribution of Dermal Multipotent Stem Cells to Bone Marrow in Sublethally Irradiated Rats
• Crucial Role of SDF-1/CXCR4 Interaction in the Recruitment of Transplanted Dermal Multipotent Cells to Sublethally Irradiated Bone Marrow
• Effects of the Nerve Growth Factor on the Survival and Wound Healing in Mice with Combined Radiation and Wound Injury
• Estimation of the Genetic Risks of Exposure to Ionizing Radiation in Humans : Current Status and Emerging Perspectives

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