A histochemical study on the interradicular septum of aged rats under the mechanical force

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The upper-left first molar of 16-month-old Fischer rats was moved mesially by 20 g of orthodontic force, in order to examine the histological alteration of the interradicular septum in the aged rats. The tooth was subjected to inclination force as well as mesial shift, showing the degenerated distal ligament around the area of bifurcation and compression of the central region of the mesial ligament. Therefore, we have observed the central region of mesial interradicular septum. In the control, a few tartrate resistant acid phosphatase (TRAP)-positive flattened osteoclasts were present on the mesial interradicular septum. Parallel osteopontin (OPN)-immunopositive lines, identical to the cement lines, were seen in the alveolar bone, due to slowly-advancing bone remodeling. On the first day of the experiment, TRAP-and ED1-positive osteoclasts were resorbing the mesial surface of the interradicular septum, and ALP-positivity was seen in cells in the mesial periodontal ligament and on the bone surface. On day 3, active osteoclastic bone resorption was still observable. ALP-positive osteoblasts were localized on the alveolar bone, interspersing among the active osteoclasts. Consistently, an intense OPN-immunoreactivity was found beneath osteoblasts, indicating deposition of bone matrix. This study demonstrated that mechanical stress could cause an immediate rise of activation of osteoclasts as early as on the first day, and induced osteoblastic activity including bone formation until the third day in the aged rats. Thus, aged rats seem to be promptly subject to osteoclastic bone resorption and subsequent osteoblastic activation under tooth movement.
日本矯正歯科学会の論文

A histochemical study on the interradicular septum of aged rats under the mechanical force

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