上顎側方拡大後の正中口蓋縫合の修復過程におけるBasic Fibroblast Growth Factor(b-FGF)の効果
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It is well known that Recombinant Basic Fibroblast Growth Factor (b-FGF) which is characterized as a growth factor for fibroblasts and capillary endothelial cells, accelerates the process of dermal wound healing. Recently, it has been reported that b-FGF promotes bone fracture healing as a result of stimulating and proliferating the osteoblasts and fibroblasts in local administration. The purpose of this study is to examine the process of collagen fiber and new bone formation of the midpalatal suture after maxillary expansion in the rats injected with b-FGF histopathologically. One hundred and eighty six male Sprague-Dawley rats weighing approximately 200g were divided into 19 groups, the 19 groups comprised of one normal control groups, 6 expansion control groups (expansion group) and 12 expansion groups injected with b-FGF (5 μg group and 50 μg group). Expect for the normal control groups, an expansion device was installed between maxillary incisors for two days. The expansion space was retained throughout the experimental period after treatment. The b-FGF was injected in midpalatal suture areas at only first day of retension. The animals were sacrificed at 1,3,5,7,10 and 14 days after expansion. The specimens were examined with Hematoxylin Eosin stain. Azan Mallory stain and Osteoid stain. The results were as follows : 1. In the b-FGF groups, many fibroblasts, osteoblasts and blood vessels were actively observed in the sutural space after maxillary expansion, as compared with the expansion group. 2. In the b-FGF groups, the blood clot and/or granulation tissue were rapidly formed in the sutural space especially in 50 μg groups, as compared with the expansion groups. 3. In the b-FGF groups, the collagen fiber bundles were formed actively and the arrangement of collagen fiber bundles became more regular especially in 50 μg groups, as compared with the expansion groups. 4. In the b-FGF groups, the new bone formation and restoration were active and extensive in the sutural space especially in 50 μg groups, as compared with the expansion groups. From these observations, it was suggested that the b-FGF stimulated and enhanced the cell proliferation and activity of fibroblasts and osteoblasts. Consequently, the b-FGF was found to be very effective in osteogenesis and for the stabilization of the midpalatal suture areas after maxillary expansion.
- 福岡歯科大学学会の論文
- 1995-06-30
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