Involvement of Syndecans in Actin Cytoskeletal Organization and Tumor Metastasis

概要

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Syndecan-2, a transmembrane heparan sulfate proteoglycan, cooperates with integrin α5β1 on cell adhesion to a fibronectin substratum and regulates actin cytoskeletal organization. A signal generated by adhesion of cells to fibronectin through integrin α5β1 alone results in cortex actin formation and through syndecan-2 alone results in a filopodium formation, but through both receptors results in the formation of stress fibers. This regulation depends on the syndecan-2-expression level, and therefore the low expresser does not form stress fibers but cortex actin. Among other syndecans expressed by the cells, syndecan-l and syndecan-3 do not participate in this signaling, but syndecan-4 seems to function upstream of syndecan-2 in the cascade, suggesting that each syndecan bears functional specificity as a receptor. We have found that there is an inverse correlation between the syndecan-2-expression level and the metastatic potential of Lewis lung carcinoma-derived clones. The fact that overexpression of syndecan-2 causes suppression of metastasis indicates that there is a causal relationship behind this correlation.
日本結合組織学会の論文
2002-09-25