XIX型コラーゲンに関する最近の知見(<特集>コラーゲン研究)

概要

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Type XIX collagen was originally discovered through cDNA cloning of RNA transcripts from the human rhabdomyosarcoma cell line RD. This molecule is a member of the fibril-associated collagen with an interrupted triple helices (FACIT) class of collagen molecules. The results of in situ hybridization demonstrate that type XIX collagen is preferentially and transiently expressed in differentiating muscle cells. Embryonic accumulation of Col19a1 transcripts in myotome and myotome derivatives closely resembles that of the myogenic regulatory factor myf-5. Col19a1 is also expressed in smooth muscle cells of the developing stomach and esophagus as well as adult brain. Ongoing generation of Col19a1 null mouse will show that type XIX collagen-rich matrices may play specialized roles during morphogenesis.
2002-06-25