Neuroglycan C, a Part-time Proteoglycan, in the Central Nervous System

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Neuroglycan C(NGC)is a 150-kDa transmembrane chondroitin sulfate proteoglycan with a 120-kDa core glycoprotein and is expressed predominantly in the brain. The core protein is divided into five structurally different domains ; an N-terminal domain to which chondroitin sulfate chain(s)may be attached, a cluster of acidic amino acids, a cysteine-rich domain with an EGF-like motif, a transmembrane domain, and a C-terminal cytoplasmic domain with two potential phosphorylation sites for protein kinase C. The mouse and human NGC genes comprise six exons, and are approximately 17 kb in size. The NGC gene is assigned to chromosomal band 9F1 in mouse, 3p21.3 in human, and 8q32.1 in rat. NGC is expressed on the surface of many neuronal cells in the cerebrum, Whereas it is expressed only on the Purkinje cells in the cerebellum. The structure of NGC changes from a proteoglycan form to a nonproteoglycan form without chondroitin sulfate side chains as the cerebellar development proceeds. Immunohistological observation suggests that NGC is involved in selective synaptogenesis on the Purkinje cells in the cerebellar development.
日本結合組織学会の論文
2000-03-25