中和抵抗変異株を用いたネコ伝染性腹膜炎ウイルスの中和抗原決定基の解析

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概要

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• The type II feline infectious peritonitis virus (FIPV) epitopes for neutralizing and enhancing antibodies are present on large spike glycoprotein (S) protein. In this study, we established monoclonal antibody-resistant mutant viruses resistant to three different monoclonal antibodies with neutralizing activity in Felis catus whole fetus cells and enhancing activity in feline macrophages, recognizing distinct epitopes on type II FIPV S protein. By comparing the nucleotide sequences of these mutant viruses with that of wild-type virus, we attempted to identify the neutralizing epitopes. The mutations were localized in the region of amino acid residues from 480 to 649 from the N terminal of the S protein.

• 1999-08-25

著者

• Koyama Hiroyuki

  Department of Biotechnology, Faculty of Agriculture, Gifu University

• HOHDATSU Tsutomu

  Department of Veterinary Infectious Disease, School of Veterinary Medicine and Animal Sciences, Kita

• Kida Koji

  Department Of Veterinary Infectious Deseases School Of Veterinary Medicine And Animal Sciences Kitas

• Hohdatsu T

  Department Of Veterinary Infectious Deseases School Of Veterinary Medicine And Animal Sciences Kitas

• FUJII Kazue

  Department of Veterinary Infectious Deseases, School of Veterinary Medicine and Animal Sciences, Kit

• Fujii Kazue

  Department Of Veterinary Infectious Deseases School Of Veterinary Medicine And Animal Sciences Kitas

• Koyama Hiroyuki

  Department Of Veterinary Infectious Deseases School Of Veterinary Medicine And Animal Sciences Kitas

• Koyama Hiroyuki

  Department Of Biotechnology Faculty Of Agriculture Gifu University

• 木田 浩司

  Department of Veterinary Infectious Deseases, School of Veterinary Medicine and Animal Sciences, Kitasato University

• 宝達 勉

  Department of Veterinary Infectious Deseases, School of Veterinary Medicine and Animal Sciences, Kitasato University

• 藤井 和恵

  Department of Veterinary Infectious Deseases, School of Veterinary Medicine and Animal Sciences, Kitasato University

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