Sensitive Determination of D-Amino Acids in Mammals and the Effect of D-Amino-Acid Oxidase Activity on Their Amounts(D-Amino Acid Biosystem)
スポンサーリンク
概要
- 論文の詳細を見る
The determination of small amounts of D-amino acids in mammalian tissues is still a challenging theme in the separation sciences. In this review, various gas-chromatographic and high-performance liquid chromatographic methods are discussed including highly selective and sensitive column-switching procedures. Based on these methods, the distributions of D-aspartic acid, D-serine, D-alanine, D-leucine and D-proline have been clarified in the mouse brain. As the regulation mechanisms of D-amino acid amounts in mammals, we focused on the D-amino-acid oxidase, which catalyzes the degradation of D-amino acids. Using the mutant mouse strain lacking D-amino-acid oxidase activity, the effects of the enzymatic activity on the amounts and distributions of various D-amino acids have been investigated.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
-
ZAITSU KIYOSHI
Graduate School of Pharmaceutical Sciences Kyushu University
-
Zaitsu K
Graduate School Of Pharmaceutical Sciences Kyushu University
-
Zaitsu Kiyoshi
九州大学 薬学研究院
-
Zaitsu K
Kyushu Univ. Fukuoka Jpn
-
KONNO Ryuichi
Department of Microbiology, Dokkyo University School of Medicine
-
Konno Ryuichi
Department Of Microbiology Dokkyo University School Of Medicine
-
Morikawa Akiko
Graduate School Of Pharmaceutical Sciences Kyushu University
-
HAMASE Kenji
Graduate School of Pharmaceutical Sciences, Kyushu University
-
Kenji Hamase
Graduate School Of Pharmaceutical Sciences Kyushu University
-
Hamase Kenji
Graduate School Of Pharmaceutical Sciences Kyushu University
-
Konno Ryuichi
Center For Medical Science International University Of Health And Welfare
関連論文
- Protein Stone Formation in an Intrapancreatic Remnant Cyst After Resection of a Choledochal Cyst
- D-アミノ酸酸化酵素遺伝子(Dao-1)とマウス第5染色体のホスホグルコムタ-ゼ遺伝子(Pgm-1)との連鎖〔英文〕
- Determination of Polyphenols with HPLC-Sensitized Chemiluminescence
- Flow Injection Analysis for Pyrogallol Using 1-Ethyl-3-(3-dimethylaminopropyl)-carbodiimide as Polyphenol Chemiluminescence Enhancer
- Chemiluminescence Derivatization of α-Keto Acids Using Aminopyrazine
- High-Performance Liquid-Chromatographic Determination of Guanosine 3',5'-Cyclic Monophosphate in Human Urine with Fluorescence Detection Using 3,4-Dimethoxyphenylglyoxal
- Determination of free D-aspartic acid, D-serine and D-alanine in the brain of mutant mice lacking D-amino-acid oxidase activity
- Attomole Analysis of Melatonin by Precolumn Derivatization Reversed-Phase Micro-HPLC
- A sensitive internal standard method for the determination of melatonin in mammals using precolumn oxidation reversed-phase high-performance liquid chromatography
- D-アミノ酸酸化酵素欠損ddY/DAO-マウスの毛色遺伝子の分析とD-アミノ酸酸化酵素遺伝子と毛色遺伝子との非連鎖〔英文〕
- Analysis of Small Amounts of D-Amino Acids and the Study of Their Physiological Functions in Mammals
- Sensitive Determination of D-Amino Acids in Mammals and the Effect of D-Amino-Acid Oxidase Activity on Their Amounts(D-Amino Acid Biosystem)
- Determination of D- and L-enantiomers of threonine and allo-threonine in mammals using two-step high-performance liquid chromatography
- D-Amino acids in mammals and their diagnostic value
- Reversed-Phase HPLC of Monosaccharides in Glycoproteins Derivatized with Aminopyrazine with Fluorescence Detection
- Non-Acidic Matrix for the Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry of Acid-Labile Compounds
- Selective Masking of Amino Groups during Fluorescence Derivatization in the Presence of a Molecular Imprint Polymer
- Sensitive Anion-Exchange HPLC of Aminopyrazine Derivatives of Saccharides Having N-Acetylated Monosaccharide at the Reducing End
- Heme-Undecapeptide Labeling on Insulin for the Immunoassay of Insulin with Chemiluminescence Detection
- Enantio-Selective Derivatization of Amino Compounds in the Presence of a Molecular Imprint Polymer
- Chemiluminescence of Polyhydroxyphenol Linked-Calix[4]arenes
- Chemiluminescence Enhancer of Polyphenols, 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide
- Activity and Substrate Specificity of D-Amino Acid Oxidase in Kidneys of Various Animals
- Spatial learning and long-term potentiation of mutant mice lacking D-amino-acid oxidase
- Alkaline Phosphatase in Various Animal Species and Heat Stability of the Enzyme in Catfish(Silurus asotus)Kidney(短報)
- A Sensitive Assay of Human Blood Platelet Cyclic Nucleotide Phosphodiesterase Activity by HPLC Using Fluorescence Derivatization and Its Application to Assessment of Cyclic Nucleotide Phosphodiesterase Inhibitors
- Chemiluminescence Derivatization of Methylglyoxal Using 2-Aminonicotinic Acid
- Japan Astrobiology Mars Project (JAMP) : Search for Microbes on The Mars Surface with Special Interest in Methane-Oxidizing Bacteria
- Protective Effects of Metallothionein I and II Against Metal- and Ultraviolet Radiation-Induced Damage in Cultured Lens Epithelial Cells
- Automated and simultaneous two-dimensional micro-high-performance liquid chromatographic determination of proline and hydroxyproline enantiomers in mammals
- Circadian changes of D-alanine and related compounds in rats and the effect of restricted feeding on their amounts
- Reversible Fluorescence Derivatization of Amino Groups Using Dansylaminomethylmaleic Acid via Its Anhydride
- Lasting Chemiluminescence of 3-Indoleglyoxylyl Chloride and Its Enhancement
- Determination of D-serine and D-alanine in the tissues and physiological fluids of mice with various D-amino-acid oxidase activities using two-dimensional high-performance liquid chromatography with fluorescence detection
- Sensitive Two-Dimensional Determination of Small Amounts of D-Amino Acids in Mammals and the Study on Their Functions
- Chemiluminescence Characteristics of N-(4-Substituted Benzyl)isoluminol