Pharmacokinetics of p-Phenylbenzoic Acid in Near-Term Fetus of the Rat

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概要

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• The pharmacokinetics of p-phenylbenzoic acid (PPBA) in near-term fetus of the rat was investigated after intramuscular injection of ^<14>C-PPBA into the fetus. The elimination rate of plasma PPBA in the isolated fetus was 15.8% of that in the non-isolated fetus. The area under the blood concentration curve in the isolated fetus was 5.2-fold higher than that in the non-isolated fetus. The transplacental clearance and the fetal tissue clearance were 0.127 ml/min and 0.0299 ml/min, respectively. The urinary and biliary excretion was less than 1.0% of the injected amount. No significant difference in various laboratory parameters or in uridine diphosphate-glucuronyltransferase activity was observed between the isolated and non-isolated fetuses.

• 公益社団法人日本薬学会の論文
• 1983-10-25

著者

• 南保 俊雄

  第一化学薬品(株)東海研究所

• 南保 俊雄

  Tokai Research Laboratories Daiichi Pure Chemicals Co. Ltd.

• 南保 俊雄

  Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd.,

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• Phospholipid Dependency of Hepatic Uridine Diphosphate-Glucuronyltransferase in the Developing Fetus of the Rat
• RI測定のための組織可溶化剤
• Pharmacokinetics of p-Phenylbenzoic Acid in Near-Term Fetus of the Rat
• Cefuroximeの生体内運命に関する研究 (Cefuroxime(CXM))
• The Electronic Effects of Benzoic Acid Substituents on Glycine Conjugation
• Influence of Dietary Lipids on Glucuronidation and Sulfation of Phenol and Its para Substituent in the Rat
• The Relationship between Van der Waals Volume of 4-Substituent of Phenol and Sulfation in the Rat
• Advance on drug metabolism analysis method.

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